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必要性序贯中间吻球囊扩张在球囊扩张支架术中的应用:金属/聚合物血管支架台架测试的进一步见解。

Necessity sequential intermediate kissing balloon dilation for crush stenting: Further insights from metal/polymer vessel scaffolds bench testing.

机构信息

Department of Cardiology, Bozhou People's Hospital, Bozhou Hospital Affiliated to Anhui University of Science and Technology, Bozhou Hospital Affiliated to Anhui Medical University, Bozhou City, Anhui Province, China.

Department of Cardiology, Union Hospital, Fujian Medical University, Provincial Institute of Coronary Artery Disease, Fujian, PR China.

出版信息

Medicine (Baltimore). 2024 Oct 25;103(43):e40243. doi: 10.1097/MD.0000000000040243.

Abstract

Sequential intermediate kissing balloon dilation (sIKBD) is crucial for crush stenting, but it require appropriate procedure remains unclear for crush stenting. This study aims to investigate whether sIKBD is necessary and how it can be properly performed during crush stenting. Mini-crush stenting (mini-CS) and sIKBD for mini-crush stenting (sIKBD-mini-CS) using metal drug-eluting stents/polymer bioresorbable vessel scaffolds (mDES/pBVS) were emulated in bifurcation models considering the branch diameter difference, and sIKBD was added to mini-CS for pretreating side-branch (SB) stent before main-branch (MB) stenting (second figure), respectively. Micro-computed tomography was used to assess the morphological parameters of bifurcated stents including length of overlapping stent segment, residual ostial stenosis of the SB, and neocarina length using quantitative methods. Further, optical coherence tomography was to analyze the incidence of stent malapposition. Quantitative analysis demonstrated that in mDES/pBVS phantom, the neocarina length (mDES: 0.45 ± 0.10 mm vs 0.30 ± 0.09 mm, P = .005; pBVS: 0.47 ± 0.11 mm vs 0.29 ± 0.09 mm, P = .001), residual ostial stenosis at the SB (mDES: 19.37 ± 8.21% vs 12.47 ± 2.05%, P = .001; pBVS: 21.89 ± 8.54% vs 9.98 ± 3.35%, P = .035), and stent malapposition in the overlapping segment (mDES: 10.29 ± 3.31% vs 3.83 ± 0.97%, P = .001; pBVS: 12.05 ± 3.87% vs 6.40 ± 1.59%, P = .003) were lower in the sIKBD-mini-CS group than those in the mini-CS group (P < .05 for all). The results of factorial analysis showed that mDES platform tended to have better morphological indicators than the pBVS platform. Adding the sIKBD to mini-CS showed better morphologic characteristics of mDES/pBVS phantoms when compared with mini-CS. Therefore, it should be considered as a critical and proper technique for crush stenting.

摘要

序贯中间吻球囊扩张(sIKBD)对 crush 支架术至关重要,但 crush 支架术仍需适当的程序尚不清楚。本研究旨在探讨 sIKBD 是否必要,以及在 crush 支架术期间如何正确进行。分别在分叉模型中模拟了使用金属药物洗脱支架/聚合物可吸收血管支架(mDES/pBVS)的微型 crush 支架术(mini-CS)和 sIKBD 用于微型 crush 支架术(sIKBD-mini-CS),并考虑了分支直径差异,分别在主支(MB)支架置入前对侧支(SB)支架进行 sIKBD 预处理(第二张图)。使用定量方法,通过 micro-CT 评估分叉支架的形态学参数,包括重叠支架节段的长度、SB 开口残余狭窄和新嵴长度。此外,还使用光学相干断层扫描(OCT)分析支架贴壁不良的发生率。定量分析表明,在 mDES/pBVS 模型中,新嵴长度(mDES:0.45±0.10mm vs 0.30±0.09mm,P=0.005;pBVS:0.47±0.11mm vs 0.29±0.09mm,P=0.001)、SB 开口残余狭窄(mDES:19.37±8.21% vs 12.47±2.05%,P=0.001;pBVS:21.89±8.54% vs 9.98±3.35%,P=0.035)和重叠节段支架贴壁不良(mDES:10.29±3.31% vs 3.83±0.97%,P=0.001;pBVS:12.05±3.87% vs 6.40±1.59%,P=0.003)在 sIKBD-mini-CS 组中均低于 mini-CS 组(P<0.05)。析因分析结果表明,mDES 平台的形态学指标优于 pBVS 平台。与 mini-CS 相比,在 mini-CS 中加入 sIKBD 可显示出更好的 mDES/pBVS 模型形态特征。因此,它应被视为 crush 支架术的一项关键和适当的技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c748/11521051/6124fa8f75bf/medi-103-e40243-g001.jpg

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