Ozer I
Arch Biochem Biophys. 1986 Feb 15;245(1):153-6. doi: 10.1016/0003-9861(86)90199-2.
The relationship between reaction order and stoichiometry in inhibition of enzymes by potentially irreversible inhibitors is discussed. It is pointed out that in an overwhelming fraction of cases reported or imagined, the order in inhibitor concentration approximates one, regardless of actual stoichiometry. It follows that reaction order should not be employed as a reliable measure of the number of amino acid residues involved in the inactivation process.
讨论了潜在不可逆抑制剂对酶抑制作用中反应级数与化学计量关系。指出在已报道或设想的绝大多数情况下，抑制剂浓度的反应级数近似为一级，而与实际化学计量无关。因此，反应级数不应被用作衡量失活过程中涉及氨基酸残基数量的可靠指标。
