产大肠杆菌素的pks⁺大肠杆菌与结直肠癌发生关联的Meta分析
A Meta-Analysis on the Association of Colibactin-Producing pks+ Escherichia coli with the Development of Colorectal Cancer.
作者信息
Gaab Marcianne Elaine, Lozano Prim Olivette, Ibañez Danica, Manese Korina Diane, Riego Fatima May, Tiongco Raphael Enrique, Albano Pia Marie
机构信息
Department of Biological Sciences, College of Science, University of Santo Tomas, Manila, Philippines.
Department of Medical Technology, College of Allied Medical Professions, Angeles University Foundation, Angeles City, Philippines.
出版信息
Lab Med. 2023 Jan 5;54(1):75-82. doi: 10.1093/labmed/lmac072.
OBJECTIVE
Previous studies on the association between pks+Escherichia coli and colorectal cancer (CRC) demonstrated conflicting results. Hence, we performed a meta-analysis to obtain more precise estimates.
METHODS
Related literature was obtained from PubMed, ScienceDirect, Google Scholar, and Cochrane Library. Data were then extracted, summarized, and subjected to analysis using Review Manager 5.4 by computing for the pooled odds ratios at the 95% confidence interval.
RESULTS
Overall analysis showed that individuals carrying pks+E coli had a greater risk of developing CRC. Subgroup analysis further showed that individuals from Western countries carrying pks+E coli and individuals with pks+E coli in their tissue samples had increased risk of developing CRC.
CONCLUSION
Results of this meta-analysis suggest that individuals with pks+E coli have a greater risk of developing CRC. However, more studies are needed to confirm our claims.
目的
先前关于携带聚酮合酶基因的大肠杆菌（pks⁺大肠杆菌）与结直肠癌（CRC）之间关联的研究结果相互矛盾。因此，我们进行了一项荟萃分析以获得更精确的估计值。
方法
从PubMed、ScienceDirect、谷歌学术和Cochrane图书馆获取相关文献。然后提取数据、进行总结，并使用Review Manager 5.4通过计算95%置信区间的合并比值比进行分析。
结果
总体分析表明，携带pks⁺大肠杆菌的个体患结直肠癌的风险更高。亚组分析进一步表明，来自西方国家且携带pks⁺大肠杆菌的个体以及组织样本中含有pks⁺大肠杆菌的个体患结直肠癌的风险增加。
结论
这项荟萃分析的结果表明，携带pks⁺大肠杆菌的个体患结直肠癌的风险更高。然而，需要更多研究来证实我们的观点。
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