鞭枝蜈蚣藻对源自肝癌大鼠模型的癌线粒体的毒性作用
Toxicity Effect of Hypnea flagelliformis Algae on Cancerous Mitochondria Obtained from Rat Model of Hepatocellular Carcinoma.
作者信息
Seydi Enayatollah, Barzegar Mahsa, Nazemi Melika, Mohsenifar Zhaleh, Shahbazi Nazanin, Jafarian-Dehkordi Abbas, Pourahmad Jalal
机构信息
Department of Occupational Health and Safety Engineering, School of Health, Alborz University of Medical Sciences, Karaj, Iran.
Research Center for Health, Safety and Environment, Alborz University of Medical Sciences, Karaj, Iran.
出版信息
Asian Pac J Cancer Prev. 2024 Dec 1;25(12):4273-4279. doi: 10.31557/APJCP.2024.25.12.4273.
BACKGROUND AND OBJECTIVE
Hepatocellular carcinoma (HCC) is recognized as one of the major public health problems and deadly malignancies worldwide. Today, the use of compounds of natural origin in the treatment of cancer and other diseases has been of interest to researchers. Marine compounds such as algae have anti-cancer effects. In addition, Sea algae have nutritional value. This research is designed to investigate the cytotoxic effects of Hypnea flagelliformis (H. flagelliformis) extracts (methanolic, diethyl ether and n-hexane) on HCC mitochondria.
MATERIAL AND METHOD
HCC was induced by diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in rats. Then, toxicity parameters were evaluated.
RESULTS
The results showed that all H. flagelliformis extracts (250, 500 and 1000 µg/ml) significantly caused toxicity in HCC mitochondria, and no effect on healthy mitochondria was reported.
CONCLUSION
The results indicate that the use of H. flagelliformis along with selected drugs in the treatment of HCC can help in the treatment of this cancer.
背景与目的
肝细胞癌（HCC）被公认为全球主要的公共卫生问题和致命恶性肿瘤之一。如今，天然来源的化合物在癌症及其他疾病治疗中的应用已引起研究人员的关注。藻类等海洋化合物具有抗癌作用。此外，海藻还具有营养价值。本研究旨在探讨鞭状沙菜（H. flagelliformis）提取物（甲醇提取物、二乙醚提取物和正己烷提取物）对肝癌细胞线粒体的细胞毒性作用。
材料与方法
用二乙基亚硝胺（DEN）和2-乙酰氨基芴（2-AAF）诱导大鼠发生肝癌。然后，评估毒性参数。
结果
结果表明，所有鞭状沙菜提取物（250、500和1000µg/ml）均显著对肝癌细胞线粒体产生毒性，且未报告对健康线粒体有影响。
结论
结果表明，在肝癌治疗中使用鞭状沙菜并结合选定药物有助于治疗这种癌症。
Zotero 插件