Stereotactic and Functional Neurosurgery Department, Jaslok Hospital and Research Centre, Mumbai, India.
Department of Anaesthesiology, Jaslok Hospital and Research Centre, Mumbai, India.
JMIR Res Protoc. 2024 Oct 29;13:e59018. doi: 10.2196/59018.
Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by motor dysfunctions and nonmotor symptoms. Current treatments do not alter disease progression, highlighting the need for alternative therapies. Music, dance, and mindfulness meditation have shown the potential to improve symptoms and quality of life in patients with PD.
This study aims to evaluate the effectiveness of dance or music and meditation on PD progression, cognitive functions, mood, behavior, and caregiver burden.
This study is a single-blinded, longitudinal, parallel, randomized controlled trial. The participants consist of 30 patients with mild to moderate PD residing in Mumbai, India, who can physically participate in the activities. The exclusion criteria include advanced PD, severe balance issues, age >80 years, and other movement disorders. Participants in the intervention group will engage in dance or music sessions and guided meditation thrice weekly for 6 months. The control group will continue their usual activities and medication. The primary outcome is the progression of PD symptoms, measured using the Unified Parkinson's Disease Rating Scale I-III, and quality of life, measured using the Parkinson's Disease Questionnaire-39. The secondary outcomes include cognitive functions (Mini-Mental State Examination), mood (Beck Depression Inventory and Parkinson Anxiety Scale), mobility (timed up and go and Berg Balance Test), behavioral disorders (Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease Rating Scale), and caregiver burden (Zarit Burden Interview and Parkinson's Disease Questionnaire-Carer).
Data collection was completed in February 2024, with 28 participants finishing the study (intervention group: n=15, 54% and control group: n=13, 46%). Data analysis is underway, with results expected to be published in December 2024.
This study aims to provide significant insights into the effectiveness of dance or music and meditation in improving the quality of life and slowing the progression of PD. The findings are anticipated to support using these nonpharmaceutical therapies as complementary approaches to managing PD.
CTRI/2023/03/051064; https://tinyurl.com/2xdus53j.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/59018.
帕金森病（PD）是一种进行性神经退行性疾病，其特征为运动功能障碍和非运动症状。目前的治疗方法并不能改变疾病的进展，这凸显了需要替代疗法的必要性。音乐、舞蹈和正念冥想已显示出改善 PD 患者症状和生活质量的潜力。
本研究旨在评估舞蹈或音乐和冥想对 PD 进展、认知功能、情绪、行为和照护者负担的影响。
这是一项单盲、纵向、平行、随机对照试验。参与者为 30 名居住在印度孟买、能够进行身体活动的轻至中度 PD 患者。排除标准包括晚期 PD、严重的平衡问题、年龄>80 岁和其他运动障碍。干预组的参与者将每周进行三次舞蹈或音乐课程和引导冥想，持续 6 个月。对照组将继续进行常规活动和药物治疗。主要结局是使用统一帕金森病评定量表 III 评估 PD 症状的进展和生活质量，使用帕金森病问卷 39 进行评估。次要结局包括认知功能（简易精神状态检查）、情绪（贝克抑郁量表和帕金森焦虑量表）、移动能力（计时起立和伯格平衡测试）、行为障碍（帕金森病冲动-强迫障碍问卷评定量表）和照护者负担（Zarit 负担访谈和帕金森病问卷-照护者）。
数据收集于 2024 年 2 月完成，28 名参与者完成了研究（干预组：n=15，54%；对照组：n=13，46%）。数据分析正在进行中，预计结果将于 2024 年 12 月公布。
本研究旨在深入了解舞蹈或音乐和冥想对改善 PD 患者生活质量和减缓疾病进展的效果。研究结果有望支持将这些非药物疗法作为 PD 管理的补充方法。
CTRI/2023/03/051064；https://tinyurl.com/2xdus53j。
国际公认的报告标识符（IRRID）：DERR1-10.2196/59018。
