溃疡性结肠炎、家族性腺瘤性息肉病和原发性结直肠癌中多灶性同步结直肠癌的比较。
A comparison of multiple synchronous colorectal cancer in ulcerative colitis, familial polyposis coli, and de novo cancer.
作者信息
Greenstein A J, Slater G, Heimann T M, Sachar D B, Aufses A H
出版信息
Ann Surg. 1986 Feb;203(2):123-8. doi: 10.1097/00000658-198602000-00002.
Multiple synchronous colorectal cancer (MSCC) among 1537 patients (69 with familial polyposis coli (FPC), 780 with ulcerative colitis (UC), and 685 with de novo colorectal (DNC) cancers) admitted to The Mount Sinai Hospital between 1945 and 1981 was tabulated. MSCC occurred in five of 24 cancer patients with FPC (21%), in 12 of 65 cancer patients with UC (18%), but in only 17 of 685 DNC patients (2.5%). The proportions of MSCC cases with more than two synchronous tumors were also much greater in the former two groups (UC 6/12 = 50%, FPC 3/5 = 60%) than in DNC (0/17 = 0%). Multiplicity of cancers is thus a distinguishing feature of UC and FPC. MSCC differed from solitary cancers by association with older age and more advanced stage at diagnosis in patients with FPC and by a rightward shift in anatomic distribution in all patients, especially those with FPC and UC.
对1945年至1981年间入住西奈山医院的1537例患者（69例患有家族性腺瘤性息肉病（FPC），780例患有溃疡性结肠炎（UC），685例患有原发性结直肠癌（DNC））中的多原发性同步结直肠癌（MSCC）进行了列表分析。在24例FPC癌症患者中有5例发生MSCC（21%），在65例UC癌症患者中有12例发生MSCC（18%），而在685例DNC患者中仅有17例发生MSCC（2.5%）。前两组（UC为6/12 = 50%，FPC为3/5 = 60%）中具有两个以上同步肿瘤的MSCC病例比例也远高于DNC组（0/17 = 0%）。因此，癌症的多发性是UC和FPC的一个显著特征。MSCC与孤立性癌症的不同之处在于，FPC患者在诊断时与年龄较大和分期较晚相关，并且在所有患者中，尤其是FPC和UC患者，其解剖分布向右偏移。
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