Burgos Fátima, Ramírez-Orrego Lourdes, Rojas Luis M, Tapia-Limonchi Rafael, Gutierrez Carmen, Chenet Stella M
Instituto de Investigación de Enfermedades Tropicales, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru.
Laboratorio Referencial de Salud Pública, Dirección Regional de Salud de Amazonas, Chachapoyas, Peru.
Am J Trop Med Hyg. 2024 Oct 29;112(1):189-193. doi: 10.4269/ajtmh.24-0280. Print 2025 Jan 8.
The increase in dengue cases in Amazonas poses a public health risk. This study aimed to examine the circulating serotypes in the region of Amazonas, Peru, from 2021 to 2023, along with the associated clinical and epidemiological characteristics. Serotype identification was determined for 420 serum samples using a multiplex real-time reverse transcription-polymerase chain reaction assay, revealing that 194 patients were infected by dengue virus (DENV)-1 and 226 by DENV-2. Both serotypes co-circulated in all affected provinces. Warning signs were more frequent in patients with DENV-2 (P = 0.004), and the manifestation of abdominal pain was correlated with this serotype (P = 0.004), highlighting its association with severe forms of the disease. In conclusion, this study emphasizes the widespread circulation of DENV-1 and DENV-2 in Amazonas. Furthermore, it underscores the importance of real-time molecular surveillance that could provide an early prognosis of disease severity.
亚马孙州登革热病例的增加构成了公共卫生风险。本研究旨在调查2021年至2023年秘鲁亚马孙地区流行的血清型，以及相关的临床和流行病学特征。使用多重实时逆转录-聚合酶链反应分析法对420份血清样本进行血清型鉴定，结果显示194例患者感染了登革热病毒（DENV）-1型，226例感染了DENV-2型。两种血清型在所有受影响省份共同流行。DENV-2型患者出现警示症状的频率更高（P = 0.004），且腹痛表现与该血清型相关（P = 0.004），突出了其与疾病严重形式的关联。总之，本研究强调了DENV-1型和DENV-2型在亚马孙州的广泛传播。此外，它强调了实时分子监测的重要性，这种监测可以对疾病严重程度提供早期预后。
