Ramos-Castañeda José, Barreto Dos Santos Flavia, Martínez-Vega Ruth, Galvão de Araujo Josélio Maria, Joint Graham, Sarti Elsa
Instituto Nacional de Salud Publica, Centro de Investigaciones sobre Enfermedades Infecciosas, Morelos, Mexico.
Laboratório de Imunologia Viral, Instituto Oswaldo Cruz/ Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
PLoS Negl Trop Dis. 2017 Jan 9;11(1):e0005224. doi: 10.1371/journal.pntd.0005224. eCollection 2017 Jan.
Dengue, the predominant arthropod-borne viral disease affecting humans, is caused by one of four distinct serotypes (DENV-1, -2, -3 or -4). A literature analysis and review was undertaken to describe the molecular epidemiological trends in dengue disease and the knowledge generated in specific molecular topics in Latin America, including the Caribbean islands, from 2000 to 2013 in the context of regional trends in order to identify gaps in molecular epidemiological knowledge and future research needs. Searches of literature published between 1 January 2000 and 30 November 2013 were conducted using specific search strategies for each electronic database that was reviewed. A total of 396 relevant citations were identified, 57 of which fulfilled the inclusion criteria. All four dengue virus serotypes were present and co-circulated in many countries over the review period (with the predominance of individual serotypes varying by country and year). The number of countries in which more than one serotype circulated steadily increased during the period under review. Molecular epidemiology data were found for Argentina, Bolivia, Brazil, the Caribbean region, Colombia, Ecuador, Mexico and Central America, Paraguay, Peru and Venezuela. Distinct lineages with different dynamics were found in each country, with co-existence, extinction and replacement of lineages occurring over the review period. Despite some gaps in the literature limiting the possibility for comparison, our review has described the molecular epidemiological trends of dengue infection. However, several gaps in molecular epidemiological information across Latin America and the Caribbean were identified that provide avenues for future research; in particular, sequence determination of the dengue virus genome is important for more precise phylogenetic classification and correlation with clinical outcome and disease severity.
登革热是影响人类的主要虫媒病毒性疾病，由四种不同血清型（DENV-1、-2、-3或-4）之一引起。开展了一项文献分析与综述，以描述登革热疾病的分子流行病学趋势，以及2000年至2013年期间拉丁美洲（包括加勒比岛屿）在特定分子主题方面所产生的知识，同时结合区域趋势，以确定分子流行病学知识方面的差距和未来的研究需求。利用针对每个所检索电子数据库的特定检索策略，对2000年1月1日至2013年11月30日期间发表的文献进行了检索。共识别出396条相关引文，其中57条符合纳入标准。在整个综述期间，所有四种登革热病毒血清型均存在且在许多国家共同流行（不同血清型的优势因国家和年份而异）。在所审查期间，有不止一种血清型流行的国家数量稳步增加。在阿根廷、玻利维亚、巴西、加勒比地区、哥伦比亚、厄瓜多尔、墨西哥和中美洲、巴拉圭、秘鲁和委内瑞拉发现了分子流行病学数据。在每个国家都发现了具有不同动态的不同谱系，在综述期间出现了谱系的共存、灭绝和替代。尽管文献中存在一些差距限制了比较的可能性，但我们的综述描述了登革热感染的分子流行病学趋势。然而，确定了拉丁美洲和加勒比地区分子流行病学信息方面的若干差距，这些差距为未来研究提供了途径；特别是，登革热病毒基因组的序列测定对于更精确的系统发育分类以及与临床结果和疾病严重程度的关联至关重要。
