Korte G E, Henkind P
Arch Ophthalmol. 1986 Feb;104(2):273-6. doi: 10.1001/archopht.1986.01050140131035.
The permeability of retinal blood vessels to intravenously injected horseradish peroxidase was examined two to seven days after bilateral common carotid ligation in rats. Light and electron microscopy revealed leakage from the blood vessels of the optic disc. This leakage appeared to result from vesicular transport across the endothelium; the interendothelial tight junctions we examined remained intact and there was no evidence of endothelial cell death. The intraretinal blood vessels and the retinal pigment epithelium retained their normal impermeability to horseradish peroxidase. Cellular edema was present at the optic disc, manifested as swollen axons. Glial cells remained normal in appearance and the extracellular space was not enlarged. These observations clarify those previously derived from funduscopy and fluorescein angiography, which revealed disc edema and hyperfluorescence.
在大鼠双侧颈总动脉结扎后两到七天，检测视网膜血管对静脉注射辣根过氧化物酶的通透性。光镜和电镜检查显示视盘血管有渗漏。这种渗漏似乎是由跨内皮的囊泡运输导致的；我们检查的内皮细胞间紧密连接保持完整，没有内皮细胞死亡的证据。视网膜内血管和视网膜色素上皮对辣根过氧化物酶仍保持正常的不透性。视盘处存在细胞水肿，表现为轴突肿胀。胶质细胞外观正常，细胞外间隙未扩大。这些观察结果澄清了先前通过眼底镜检查和荧光素血管造影得出的结果，后者显示视盘水肿和荧光增强。
