Spatz M, Mrsulja B B, Wroblewska B, Merkel N, Bembry J
Biochem Biophys Res Commun. 1986 Jan 29;134(2):484-91. doi: 10.1016/s0006-291x(86)80446-6.
The separately cultured smooth muscle and endothelial cells derived from dissociated cerebral microvessels are characterized by high content of glycogen. Norepinephrine induces glycogenolysis while 5-hydroxytryptamine stimulates glycogenesis in both cell types. The endogenous glucose of the endothelium but not that of the smooth muscle serves as a direct source for the 5-HT enhancement of glycogen formation. Indomethacin, the known inhibitor of cyclooxygenase modulates the glycogen content in the smooth muscle only. These findings strongly suggest that the carbohydrate metabolism of each cell has a distinct control mechanism compatible with the underlying integral microvascular function.
从解离的脑微血管中分离培养的平滑肌细胞和内皮细胞的特点是糖原含量高。去甲肾上腺素诱导糖原分解，而5-羟色胺在两种细胞类型中均刺激糖原合成。内皮细胞而非平滑肌细胞的内源性葡萄糖是5-羟色胺增强糖原形成的直接来源。已知的环氧化酶抑制剂吲哚美辛仅调节平滑肌中的糖原含量。这些发现有力地表明，每种细胞的碳水化合物代谢都有一种与潜在的整体微血管功能相适应的独特控制机制。
