Li Hanyue, Yin Nuoya, Yang Renjun, Faiola Francesco
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China.
Environ Health (Wash). 2024 Feb 28;2(6):332-349. doi: 10.1021/envhealth.3c00199. eCollection 2024 Jun 21.
In recent years, rapid industrial development has resulted in the production and exposure of a substantial number of compounds to the human body. This has created an urgent need in environmental toxicology for models that are efficient, accurate, and cost-effective in evaluating the health impacts of these compounds on humans. Over the past seven decades, various cancer cell lines and immortalized cell lines have made significant contributions to the advancement of research on organ toxicity. Pluripotent stem cell technology, especially toxicological models derived from pluripotent stem cells, presents modern environmental toxicologists with high-throughput, species-relevant, and predictive options. In this comprehensive review, we assess the characteristics of representative human cancer cell lines and immortalized cell lines in environmental toxicology, as well as introduce two distinct human pluripotent stem cell types and their innovative toxicological models. We explore their applications and prospects in the field of environmental toxicology, while also addressing the readiness of models to confront the emerging challenges of the future.
近年来，快速的工业发展导致大量化合物产生并进入人体。这使得环境毒理学迫切需要高效、准确且经济高效的模型，用于评估这些化合物对人类健康的影响。在过去的七十年里，各种癌细胞系和永生化细胞系为器官毒性研究的进展做出了重大贡献。多能干细胞技术，尤其是源自多能干细胞的毒理学模型，为现代环境毒理学家提供了高通量、与物种相关且具有预测性的选择。在这篇综述中，我们评估了环境毒理学中代表性人类癌细胞系和永生化细胞系的特征，介绍了两种不同的人类多能干细胞类型及其创新的毒理学模型。我们探讨了它们在环境毒理学领域的应用和前景，同时也讨论了这些模型应对未来新挑战的准备情况。
