Kar Yeter Duzenli, Yildirgan Duygu Ozkorucu, Aygun Belkis, Erdogmus Demet, Altinkaynak Konca
Division of Pediatric Hematology-Oncology, Department of Pediatrics, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
Department of Hemovigilans, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
North Clin Istanb. 2021 May 24;8(3):261-268. doi: 10.14744/nci.2020.76258. eCollection 2021.
Transfusion of blood and blood components is a special type of tissue transplantation, a life-saving treatment. However, besides the benefits of blood product transfusions, there are also some undesirable side effects. In the present study, the frequency and type of transfusion reactions related to blood and blood components were investigated.
In this retrospective study, types and the time of occurrence of acute transfusion reaction (ATR), the types of blood and blood components used in our hospital between January 2018 and January 2020 were evaluated for hemovigilance using unit blood products application and side effect reporting forms.
During the 2-year period, 61,636 blood and/or blood components were used in 9334 patients, and 53 of the transfused patients developed ATR. In two patients, ATR developed 2 times and a total of 55 ATR developed. Of the patients who developed ATR, 18 were female and 35 were male, and their ages ranged from 1 month to 85 years. The frequency of ATR was 0.09%, and 47.3% of ATRs were allergic transfusion reactions, 41.8% were febrile non-hemolytic transfusion reactions (FNHTRs), 7.3% were hypotensive transfusion reactions, and 1.8% were transfusion-related lung injury. Fifty-five ATRs were found to be associated with 61.8% erythrocyte suspension, 30.9% with FFP, 5.5% with platelet suspension, and 1.8% with whole blood.
There are a limited number of studies evaluating transfusion reaction frequency and reaction types from our country. The most frequent ATR reported in our hospital were mild allergic reactions and FNHTR. The most common side effect of blood product type was erythrocyte suspension. It is important to monitor the transfused patients for undesired reactions during and after the transfusion to determine the frequency, type, risk factors, and safety precautions of the transfusion reactions.
输血及血液成分输注是一种特殊的组织移植，是一种挽救生命的治疗方法。然而，除了血液制品输注的益处外，也存在一些不良副作用。在本研究中，对与血液及血液成分相关的输血反应的频率和类型进行了调查。
在这项回顾性研究中，使用单份血液制品应用和副作用报告表，对2018年1月至2020年1月我院急性输血反应（ATR）的类型和发生时间、所使用的血液及血液成分类型进行了血液警戒评估。
在这2年期间，9334例患者使用了61636单位血液及/或血液成分，其中53例输血患者发生了ATR。2例患者发生了2次ATR，共发生55次ATR。发生ATR的患者中，女性18例，男性35例，年龄范围为1个月至85岁。ATR的发生率为0.09%，其中47.3%为过敏性输血反应，41.8%为发热性非溶血性输血反应（FNHTR），7.3%为低血压性输血反应，1.8%为输血相关肺损伤。发现55次ATR与61.8%的红细胞悬液、30.9%的新鲜冰冻血浆、5.5%的血小板悬液和1.8%的全血有关。
我国评估输血反应频率和反应类型的研究数量有限。我院报告的最常见ATR为轻度过敏反应和FNHTR。血液制品类型最常见的副作用是红细胞悬液。在输血期间和输血后监测输血患者的不良反应，以确定输血反应的频率、类型、危险因素和安全预防措施非常重要。
