Bertouch J V, Roberts-Thomson P J, Smith M D, Woodruff T G, Brooks P M, Bradley J
Arthritis Rheum. 1986 Jan;29(1):32-8. doi: 10.1002/art.1780290105.
Paired samples of synovial fluid (SF) and blood were obtained prior to and at 4 and 24 hours following high-dose methylprednisolone infusion therapy in a group of patients with refractory rheumatoid arthritis. After therapy there was a significant decrease in numbers of polymorphonuclear leukocytes, lymphocytes, immune complexes, and C-reactive protein in the SF. Measurement of lymphocyte subsets, using monoclonal antibodies, revealed that at 4 hours postinfusion, there was a disproportionate decrease in the percentage of SF lymphocytes expressing class II antigens (HLA-DR or Ia-like). These data suggest that glucocorticoids induce rapid changes in SF indices of disease activity and may directly influence T cell activation within the rheumatoid joint.
在一组难治性类风湿关节炎患者中，于大剂量甲泼尼龙输注治疗前、治疗后4小时和24小时采集配对的滑液（SF）和血液样本。治疗后，滑液中的多形核白细胞、淋巴细胞、免疫复合物和C反应蛋白数量显著减少。使用单克隆抗体对淋巴细胞亚群进行检测发现，输注后4小时，表达II类抗原（HLA-DR或Ia样）的滑液淋巴细胞百分比下降不成比例。这些数据表明，糖皮质激素可迅速改变滑液中的疾病活动指标，并可能直接影响类风湿关节内的T细胞活化。
