van der Stam Amber H, Shmuely Sharon, de Vries Nienke M, Thijs Roland D, van Kesteren-Biegstraaten Mirjam, Bloem Bastiaan R
Department of Neurology, Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Case Rep Neurol. 2024 Sep 17;16(1):256-261. doi: 10.1159/000541424. eCollection 2024 Jan-Dec.
Orthostatic hypotension is common in people with Parkinson's disease (PD) due to autonomic dysfunction and medication use and can have a significant negative impact on quality of life. Pharmacological treatment is often complicated due to complex blood pressure regulation problems. This case report presents a patient whose symptoms of orthostatic intolerance were successfully treated with the non-pharmacological method of head-up tilt sleeping (HUTS).
A 69-year-old man with PD and prominent autonomic failure received recommendation from the neurologist to use HUTS to battle orthostatic intolerance, of which complaints were worst in the early morning. The patient noted a marked improvement of the orthostatic intolerance after a period in which he slowly step-by-step inclined the bed to an angle just over 10°. When ceasing HUTS for a brief period, complaints of orthostatic intolerance immediately returned and the patient returned to tilted sleeping right away. After a follow-up of 3 months, the patient did not report orthostatic intolerance during a standing test.
This case illuminates that, despite difficulties intrinsic to this method, whole-body HUTS can ameliorate orthostatic intolerance and improve the daily life of people with advanced movement disorders.
由于自主神经功能障碍和药物使用,直立性低血压在帕金森病(PD)患者中很常见,并且会对生活质量产生重大负面影响。由于复杂的血压调节问题,药物治疗往往很复杂。本病例报告介绍了一名患者,其直立不耐受症状通过头高位倾斜睡眠(HUTS)的非药物方法得到成功治疗。
一名69岁患有PD且伴有明显自主神经功能衰竭的男性患者,接受神经科医生的建议,采用HUTS来对抗直立不耐受,患者称清晨时症状最为严重。在患者将床逐步缓慢倾斜至略超过10°的角度一段时间后,他注意到直立不耐受症状有明显改善。当短暂停止HUTS时,直立不耐受的症状立即复发,患者随即恢复倾斜睡眠。经过3个月的随访,患者在站立测试中未报告直立不耐受情况。
本病例表明,尽管该方法存在固有困难,但全身HUTS可改善直立不耐受,并改善晚期运动障碍患者的日常生活。