Zou Jiyuan, Su Zhikang, Ren Wen, Ye Yunxin, Yang Xuechao, Luo Tao, Yang Li, Guo Lvhua
Department of Endodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong, People's Republic of China.
Department of Prosthodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction and Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
Biomater Res. 2024 Oct 29;28:0100. doi: 10.34133/bmr.0100. eCollection 2024.
The emergence of multidrug-resistant (MDR) bacterial infections, particularly in diabetic wounds, represents a major challenge in clinical care due to their high mortality rate. Despite the continued use of antibiotics as the primary clinical treatment for diabetic wounds, there is an urgent need to develop antibiotic-free therapeutic strategies to combat MDR bacteria, given the limitations and resistance of antibiotics. In this study, a "nanotank", MXene@MOF@CORM-401 (MMC), was designed to target bacteria. The basis of this approach is the combination of 2-dimensional transition metal carbides/carbon nitrides (MXene), metal-organic frameworks (MOFs), and carbon monoxide-releasing molecules (CORMs). MMCs exhibit photothermal and photodynamic properties upon irradiation with near-infrared laser. The photodynamic effect generates a substantial quantity of reactive oxygen species, which subsequently triggers the release of carbon monoxide in a "gas bombs"-like manner. In vitro and in vivo experiments have demonstrated that MMC is not only biocompatible but also exhibits robust antimicrobial properties and accelerates diabetic wound healing. Consequently, this innovative 2-dimensional "nanotank" represents a promising alternative to conventional antibiotic therapies for the treatment of MDR bacterial infections in the future.
多重耐药（MDR）细菌感染的出现，尤其是在糖尿病伤口中，因其高死亡率而成为临床护理中的一项重大挑战。尽管抗生素仍作为糖尿病伤口的主要临床治疗手段持续使用，但鉴于抗生素的局限性和耐药性，迫切需要开发无抗生素的治疗策略来对抗多重耐药细菌。在本研究中，一种“纳米罐”，即MXene@MOF@CORM-401（MMC），被设计用于靶向细菌。这种方法的基础是二维过渡金属碳化物/碳氮化物（MXene）、金属有机框架（MOF）和一氧化碳释放分子（CORM）的结合。MMC在近红外激光照射下表现出光热和光动力特性。光动力效应产生大量活性氧物种，随后以“气体炸弹”般的方式触发一氧化碳的释放。体外和体内实验表明，MMC不仅具有生物相容性，还表现出强大的抗菌性能，并能加速糖尿病伤口愈合。因此，这种创新的二维“纳米罐”代表了未来治疗多重耐药细菌感染的一种有前景的替代传统抗生素疗法的方法。
