Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China.
Health Science Center, Peking University, Beijing 100191, China.
World J Gastroenterol. 2024 Oct 7;30(37):4090-4103. doi: 10.3748/wjg.v30.i37.4090.
() colonizes the human stomach and many studies have discussed the mechanisms of infection leading to gastric diseases, including gastric cancer. Additionally, increasing data have shown that the infection of may contribute to the development of extra-gastric diseases and tumors. Inflammation, systemic immune responses, microbiome disorders, and hypergastrinemia caused by infection are associated with many extra-gastric malignancies. This review highlights recent discoveries; discusses the relationship between and various extra-gastric tumors, such as colorectal cancer, lung cancer, cholangiocarcinoma, and gallbladder carcinoma; and explores the mechanisms of extra-gastric carcinogenesis by . Overall, these findings refine our understanding of the pathogenic processes of , provide guidance for the clinical treatment and management of -related extra-gastric tumors, and help improve prognosis.
幽门螺杆菌定植于人类胃部，许多研究探讨了导致胃部疾病（包括胃癌）的感染机制。此外，越来越多的数据表明，幽门螺杆菌感染可能导致胃部以外的疾病和肿瘤的发生。幽门螺杆菌感染引起的炎症、全身免疫反应、微生物失调和高胃泌素血症与许多胃部以外的恶性肿瘤有关。本综述强调了最近的发现；讨论了幽门螺杆菌与各种胃部以外的肿瘤（如结直肠癌、肺癌、胆管癌和胆囊癌）之间的关系；并探讨了幽门螺杆菌引起胃部以外肿瘤发生的机制。总之，这些发现深化了我们对幽门螺杆菌致病过程的理解，为与幽门螺杆菌相关的胃部以外肿瘤的临床治疗和管理提供了指导，并有助于改善预后。
