() colonizes the human stomach and many studies have discussed the mechanisms of infection leading to gastric diseases, including gastric cancer. Additionally, increasing data have shown that the infection of may contribute to the development of extra-gastric diseases and tumors. Inflammation, systemic immune responses, microbiome disorders, and hypergastrinemia caused by infection are associated with many extra-gastric malignancies. This review highlights recent discoveries; discusses the relationship between and various extra-gastric tumors, such as colorectal cancer, lung cancer, cholangiocarcinoma, and gallbladder carcinoma; and explores the mechanisms of extra-gastric carcinogenesis by . Overall, these findings refine our understanding of the pathogenic processes of , provide guidance for the clinical treatment and management of -related extra-gastric tumors, and help improve prognosis.