患者人格特征对口服抗癌药物依从性的影响：一个机会？
Impact of Patient Personality on Adherence to Oral Anticancer Medications: An Opportunity?
机构信息
Department of Pharmaceutical Scienes, University of California, Irvine, Irvine, CA, United States.
Department of Radiological Sciences, University of California, Irvine, Orange, CA, United States.
出版信息
JMIR Cancer. 2024 Oct 30;10:e57199. doi: 10.2196/57199.
Adherence to prescribed oral anticancer therapy is an important determinant of patient outcomes, including progression-free and overall survival. While many factors (eg, medication side effects and out-of-pocket costs, problems with insurance authorization, and timely medication refills) can affect adherence, one that is relatively unexplored is the impact of a patient's attitude and personality. Patient personality influences medication adherence and persistence in nonmalignant chronic conditions such as cardiovascular disease and diabetes. In breast cancer and chronic myeloid leukemia, studies suggest that personality also affects adherence to oral chemotherapy which can be targeted to improve adherence. In this viewpoint, we highlight the opportunity of incorporating patient personality as interventions to oral cancer therapy adherence and discuss current barriers to implementation.
遵医嘱服用抗癌药物是影响患者预后的重要决定因素，包括无进展生存期和总生存期。虽然许多因素（如药物副作用和自付费用、保险授权问题以及及时补充药物）会影响患者的服药依从性，但一个相对未被充分研究的因素是患者的态度和个性。患者个性会影响非恶性慢性疾病（如心血管疾病和糖尿病）的药物依从性和持久性。在乳腺癌和慢性髓性白血病中，研究表明个性也会影响口服化疗药物的依从性，而针对这些因素可以提高患者的服药依从性。在本观点中，我们强调了将患者个性纳入口服癌症治疗依从性干预措施的机会，并讨论了目前实施这些措施的障碍。
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