Department of Hepatobiliary Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.
School of Environment, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, 510632, China; School of Environmental Studies, China University of Geosciences, Wuhan, 430074, China.
Environ Res. 2024 Dec 15;263(Pt 3):120251. doi: 10.1016/j.envres.2024.120251. Epub 2024 Oct 29.
Bisphenols (BPs) are widely distributed in daily life as typical endocrine disruptors. In this study, we examined the distribution of bisphenol A (BPA) and BPA alternatives in liver (n = 149) and bile (n = 102) tissues from the patients with liver cancer, and calculated the hepatobiliary transport efficiency of BPs (T). Seven BPs were detected in both liver (median: 0.859 ng/g; range: 0.0200-26.7 ng/g) and bile (median: 0.307 ng/mL; range: 0.0200-26.7 ng/mL), and BPA was the predominant in both liver (mean: 1.89 ng/g) and bile (mean: 1.65 ng/mL). The T of BPs was reported for the first time and found to be negatively correlated with the molecular weight and Log K of BPs. Furthermore, BPA and ∑BPs in liver showed a significant negative correlation with age, and a significant difference was found in BPs in liver and bile in hepatocellular carcinoma patients with different genders (p < 0.05). For liver function indicators, levels of BPs showed significant positive correlation with γ-glutamyl transferase (GGT) and alanine aminotransferase (ALT), especially BPBP levels in bile. This suggests that BPs may have some correlation with hepatocellular carcinoma. This is the first report on distribution characteristics of BPs in the liver and bile of hepatocellular carcinoma patients, and is the first study to report the hepatobiliary transport efficiency of BPs. The results should contribute to the understanding of BPs accumulation in the liver and bile and further relationship with hepatocellular carcinoma.
双酚类物质（BPs）作为典型的内分泌干扰物，广泛存在于日常生活中。在本研究中，我们检测了肝癌患者肝脏（n=149）和胆汁（n=102）组织中双酚 A（BPA）和 BPA 替代品的分布，并计算了 BPs 的肝胆转运效率（T）。在肝脏（中位数：0.859ng/g；范围：0.0200-26.7ng/g）和胆汁（中位数：0.307ng/mL；范围：0.0200-26.7ng/mL）中均检测到 7 种 BPs，且 BPA 在肝脏（均值：1.89ng/g）和胆汁（均值：1.65ng/mL）中均占主导地位。首次报道了 BPs 的 T，并发现其与 BPs 的分子量和 Log K 呈负相关。此外，肝脏中 BPA 和∑BPs 与年龄呈显著负相关，且不同性别肝癌患者肝脏和胆汁中的 BPs 存在显著差异（p<0.05）。对于肝功能指标，BPs 水平与γ-谷氨酰转移酶（GGT）和丙氨酸氨基转移酶（ALT）呈显著正相关，尤其是胆汁中的 BPBP 水平。这表明 BPs 可能与肝癌有一定的相关性。这是首次报道肝癌患者肝脏和胆汁中 BPs 的分布特征，也是首次报道 BPs 的肝胆转运效率。研究结果有助于了解 BPs 在肝脏和胆汁中的积累及其与肝癌的进一步关系。
