Smazal Anne L, Almgren-Bell Alison E, Silverglade Jonah M, Bonner Lauren B, Dozier Ann, Van Horn Linda, Josefson Jami, Robinson Daniel T
Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
J Clin Transl Sci. 2024 Oct 8;8(1):e144. doi: 10.1017/cts.2024.572. eCollection 2024.
Enrollment into a prospective cohort study of mother-preterm infant dyads during the COVID-19 pandemic progressed slower than anticipated. Enrollment occurred during the first week after preterm birth, while infants were still hospitalized. We hypothesized that slower enrollment was attributable to mothers testing positive for COVID-19 as hospital policies restricted them from entering the neonatal intensive care unit, thus reducing interactions with research staff. However, only 4.5% of 245 screened mothers tested COVID-19 positive. Only 24.9% of those screened, far fewer than anticipated, were eligible for enrollment. Assumptions about pandemic-related enrollment barriers were not substantiated in this pediatric cohort.
在新冠疫情期间，一项针对母婴早产二元组的前瞻性队列研究的入组进展比预期要慢。入组在早产出生后的第一周进行，当时婴儿仍住院。我们推测入组较慢是因为新冠病毒检测呈阳性的母亲，由于医院政策限制她们进入新生儿重症监护病房，从而减少了与研究人员的互动。然而，在245名接受筛查的母亲中，只有4.5%的新冠病毒检测呈阳性。在接受筛查的人中，只有24.9%符合入组条件，远低于预期。在这个儿科队列中，关于与疫情相关的入组障碍的假设没有得到证实。
