Mitsuhashi Takumi, Iimura Yasushi, Suzuki Hiroharu, Ueda Tetsuya, Nishioka Kazuki, Nomura Kazuki, Nakajima Madoka, Sugano Hidenori, Kondo Akihide
Department of Neurosurgery, Juntendo University, Tokyo, Japan.
Epilepsy Center, Juntendo University Hospital, Tokyo, Japan.
Front Neurol. 2024 Oct 16;15:1380644. doi: 10.3389/fneur.2024.1380644. eCollection 2024.
To determine the optimal montage and vocalization conditions for high-gamma language mapping using stereoelectroencephalography.
We studied 12 epilepsy patients who underwent invasive monitoring with depth electrodes and measurement of auditory-naming related high-gamma modulations. We determined the effects of electrode montage and vocalization conditions of the response on the high-gamma (60-140 Hz) amplitudes.
Compared to common average reference montage, bipolar and Laplacian montages effectively reduced the degree of auditory naming-related signal deflections in the white matter during the stimulus and response phases (mixed model estimate: -21.2 to -85.4%; < 0.001), while maintaining those at the cortical level (-4.4 to +7.8%; = 0.614 to 0.085). They also reduced signal deflections outside the brain parenchyma during the response phase (-90.6 to -91.2%; < 0.001). Covert responses reduced signal deflections outside the brain parenchyma during the response phase (-17.0%; = 0.010).
On depth electrode recording, bipolar and Laplacian montages are suitable for measuring auditory naming-related high-gamma modulations in gray matter. The covert response may highlight the gray matter activity.
This study helps establish the practical guidelines for high-gamma language mapping using stereoelectroencephalography.
确定使用立体脑电图进行高伽马语言映射的最佳电极组合和发声条件。
我们研究了12例接受深度电极侵入性监测并测量听觉命名相关高伽马调制的癫痫患者。我们确定了电极组合和反应的发声条件对高伽马（60 - 140Hz）振幅的影响。
与普通平均参考电极组合相比，双极和拉普拉斯电极组合在刺激和反应阶段有效降低了白质中听觉命名相关信号偏转的程度（混合模型估计：-21.2%至-85.4%；<0.001），同时在皮质水平保持不变（-4.4%至+7.8%；=0.614至0.085）。它们还降低了反应阶段脑实质外的信号偏转（-90.6%至-91.2%；<0.001）。隐蔽反应降低了反应阶段脑实质外的信号偏转（-17.0%；=0.010）。
在深度电极记录中，双极和拉普拉斯电极组合适用于测量灰质中听觉命名相关的高伽马调制。隐蔽反应可能突出灰质活动。
本研究有助于建立使用立体脑电图进行高伽马语言映射的实用指南。
