Ohashi Kazumasa, Kunitomi Aoi, Chiba Shuhei, Mizuno Kensaku
Department of Molecular and Chemical Life Sciences, Laboratory of Molecular and Cellular Biology, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, Japan.
Front Cell Dev Biol. 2024 Oct 16;12:1485725. doi: 10.3389/fcell.2024.1485725. eCollection 2024.
Rho guanine nucleotide exchange factors (RhoGEFs) comprise a wide range of proteins with a common domain responsible for the activation of the Rho family of small GTPases and various domains in other regions. The evolutionary divergence of RhoGEFs enables actin cytoskeletal reorganization, leading to complex cellular responses in higher organisms. In this review, we address the involvement of RhoGEFs in the mechanical stress response of mammalian cells. The cellular mechanical stress response is essential for the proper and orderly regulation of cell populations, including the maintenance of homeostasis, tissue morphogenesis, and adaptation to the mechanical environment. In particular, this review focuses on the recent findings regarding the Dbl family of RhoGEFs involved in mechanical stress responses at the cell-cell and cell-substrate adhesion sites, and their molecular mechanisms underlying actin cytoskeleton remodeling and signal transduction.
Rho鸟嘌呤核苷酸交换因子（RhoGEFs）由多种蛋白质组成，这些蛋白质具有一个共同结构域，负责激活小GTP酶的Rho家族，以及其他区域的各种结构域。RhoGEFs的进化差异能够实现肌动蛋白细胞骨架的重组，从而在高等生物中引发复杂的细胞反应。在本综述中，我们探讨了RhoGEFs在哺乳动物细胞机械应激反应中的作用。细胞机械应激反应对于细胞群体的正常有序调节至关重要，包括维持体内平衡、组织形态发生以及对机械环境的适应。特别是，本综述重点关注了关于参与细胞-细胞和细胞-基质粘附位点机械应激反应的RhoGEFs的Dbl家族的最新发现，以及它们在肌动蛋白细胞骨架重塑和信号转导方面的分子机制。
