从进化角度看细胞骨架。
Overview of the Cytoskeleton from an Evolutionary Perspective.
机构信息
Departments of Molecular Cellular and Developmental Biology, Molecular Biophysics and Biochemistry, and Cell Biology, Yale University, New Haven, Connecticut 06520-8103.
Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
出版信息
Cold Spring Harb Perspect Biol. 2018 Jul 2;10(7):a030288. doi: 10.1101/cshperspect.a030288.
Abstract
Organisms in the three domains of life depend on protein polymers to form a cytoskeleton that helps to establish their shapes, maintain their mechanical integrity, divide, and, in many cases, move. Eukaryotes have the most complex cytoskeletons, comprising three cytoskeletal polymers-actin filaments, intermediate filaments, and microtubules-acted on by three families of motor proteins (myosin, kinesin, and dynein). Prokaryotes have polymers of proteins homologous to actin and tubulin but no motors, and a few bacteria have a protein related to intermediate filament proteins.
摘要
生命的三个域中的生物体依赖于蛋白质聚合物来形成细胞骨架，这有助于建立它们的形状，维持它们的机械完整性，分裂，并且在许多情况下，移动。真核生物具有最复杂的细胞骨架，由三种细胞骨架聚合物（肌动蛋白丝、中间丝和微管）组成，由三种肌球蛋白、驱动蛋白和动力蛋白家族的马达蛋白作用。原核生物具有与肌动蛋白和微管蛋白同源的蛋白质聚合物，但没有马达，少数细菌有一种与中间丝蛋白相关的蛋白质。
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