Du Yunpeng, Dong Shuhan, Zou Wei
Heilongjiang University of Chinese Medicine, Harbin, China.
First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
Front Cell Neurosci. 2024 Oct 16;18:1460262. doi: 10.3389/fncel.2024.1460262. eCollection 2024.
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system CNS characterized by demyelination, inflammation, and neurodegenerative changes, making it the most common nontraumatic disabling neurological disease in young adults. While current pharmacological treatments primarily target immunomodulation or immunosuppression, exercise is gaining increasing attention from the scientific community as an adjunctive therapy. This review explores the potential biological mechanisms of exercise in animal models of MS, focusing on its effects on neuroprotection and inflammation. The review examines how exercise inhibits pro-inflammatory microglial reactivity, stabilizes the blood-brain barrier, and enhances neurotrophic factor expression in animal studies. Future research directions are proposed by summarizing the evidence and limitations of existing animal models of MS, emphasizing the need to further validate these mechanisms in humans to better integrate exercise into the comprehensive management of MS. Additionally, investigating exercise-induced biomarkers for MS symptom reduction may provide a scientific basis for new therapeutic strategies.
多发性硬化症（MS）是一种中枢神经系统（CNS）的免疫介导疾病，其特征为脱髓鞘、炎症和神经退行性变，这使其成为年轻成年人中最常见的非创伤性致残性神经疾病。虽然目前的药物治疗主要针对免疫调节或免疫抑制，但运动作为一种辅助治疗方法正日益受到科学界的关注。本综述探讨了运动在MS动物模型中的潜在生物学机制，重点关注其对神经保护和炎症的影响。该综述研究了在动物研究中运动如何抑制促炎性小胶质细胞反应性、稳定血脑屏障并增强神经营养因子表达。通过总结现有MS动物模型的证据和局限性，提出了未来的研究方向，强调需要在人体中进一步验证这些机制，以便更好地将运动纳入MS的综合管理。此外，研究运动诱导的可减轻MS症状的生物标志物可能为新的治疗策略提供科学依据。
