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自体替代细胞来源向角膜上皮细胞转分化的研究进展

Progress in Transdifferentiation of Autologous Alternative Cell Sources into Corneal Epithelial Cells.

作者信息

Wang Bei, Zhao Jiang-Lan, Cai Wan-Ying, Wang Gong-Yue, Li Yu-Zhi, Wang Jia-Song, Xie Hua-Tao, Zhang Ming-Chang

机构信息

Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

出版信息

Stem Cell Rev Rep. 2025 Jan;21(1):226-235. doi: 10.1007/s12015-024-10808-1. Epub 2024 Oct 31.

DOI:10.1007/s12015-024-10808-1
PMID:39480612
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11762461/
Abstract

Corneal limbal epithelial stem cells (LESCs) play a crucial role in corneal epithelium regeneration. Severe damage to these cells can result in limbal stem cell deficiency (LSCD), characterized by repeated corneal conjunctivalization, leading to corneal turbidity and scar formation. Restoring functional LESCs and their ecological location are essential for treating LSCD. The goal of this review is to provide researchers and clinicians with key insights into LESCs biology and to conclude the current cell-based therapies advancement in LSCD treatments. Therapeutic cell resources mainly include mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), skin keratinocyte stem cells (SKCs), and oral mucosal epithelial cells (OMECs).

摘要

角膜缘上皮干细胞（LESCs）在角膜上皮再生中起着关键作用。这些细胞的严重损伤可导致角膜缘干细胞缺乏症（LSCD），其特征为角膜反复结膜化，进而导致角膜混浊和瘢痕形成。恢复功能性LESCs及其生态位对于治疗LSCD至关重要。本综述的目的是为研究人员和临床医生提供有关LESCs生物学的关键见解，并总结目前基于细胞的疗法在LSCD治疗方面的进展。治疗性细胞资源主要包括间充质干细胞（MSCs）、胚胎干细胞（ESCs）、诱导多能干细胞（iPSCs）、皮肤角质形成细胞干细胞（SKCs）和口腔黏膜上皮细胞（OMECs）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b028/11762461/3775ac8d0fe8/12015_2024_10808_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b028/11762461/3775ac8d0fe8/12015_2024_10808_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b028/11762461/3775ac8d0fe8/12015_2024_10808_Fig1_HTML.jpg

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Int J Mol Sci. 2022 Mar 12;23(6):3078. doi: 10.3390/ijms23063078.
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Derivation and Characterization of EGFP-Labeled Rabbit Limbal Mesenchymal Stem Cells and Their Potential for Research in Regenerative Ophthalmology.绿色荧光蛋白标记的兔角膜缘间充质干细胞的分离与鉴定及其在再生眼科研究中的潜力
Biomedicines. 2021 Sep 1;9(9):1134. doi: 10.3390/biomedicines9091134.
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Can Human Oral Mucosa Stem Cells Differentiate to Corneal Epithelia?
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Int J Mol Sci. 2021 Jun 1;22(11):5976. doi: 10.3390/ijms22115976.
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Recent Advances in Stem Cell Therapy for Limbal Stem Cell Deficiency: A Narrative Review.角膜缘干细胞缺乏症的干细胞治疗最新进展：一项叙述性综述。
Ophthalmol Ther. 2020 Dec;9(4):809-831. doi: 10.1007/s40123-020-00305-2. Epub 2020 Sep 24.
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Expansion of Human Limbal Epithelial Stem/Progenitor Cells Using Different Human Sera: A Multivariate Statistical Analysis.使用不同人血清扩增人角膜缘上皮干细胞/祖细胞：多变量统计分析。
Int J Mol Sci. 2020 Aug 25;21(17):6132. doi: 10.3390/ijms21176132.
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