From the Department of Small Animal Clinical Sciences (D.B.A., A.H.), University of Florida, Gainesville, Florida.
College of Veterinary Medicine, University of Florida, Gainesville, Florida (I.L.).
J Am Anim Hosp Assoc. 2024 Nov 1;60(6):265-269. doi: 10.5326/JAAHA-MS-7453.
An approximately 3 yr old female Chihuahua was presented for evaluation of polyuria and polydipsia noted by the owner after adoption. Serum biochemistry and urinalysis revealed hyponatremia, hypochloremia, hypo-osmolality, and normal fractional excretion of sodium. Serum antidiuretic hormone concentration was 5.54 pg/mL and serum copeptin concentration was 135.40 pg/mL. The antidiuretic hormone value was above the reported range for healthy dogs and was considered inappropriate in light of serum osmolality. Idiopathic syndrome of inappropriate antidiuretic hormone secretion was considered the most likely diagnosis after excluding other potential causes, such as diuretic use, renal disease, adrenal disease, and thyroid dysfunction. The dog remains clinically well 2 yr after diagnosis without specific treatment other than minimal dietary salt supplementation. This case is unique because of the absence of systemic or neurologic signs, good long-term outcome without treatment, and use of novel diagnostic testing.
一只约 3 岁的雌性吉娃娃犬，被新主人收养后，出现多尿和多饮，主人带其前来就诊。血清生化和尿液分析显示低钠血症、低氯血症、低渗透压和正常的钠分数排泄。血清抗利尿激素浓度为 5.54pg/mL，血清 copeptin 浓度为 135.40pg/mL。抗利尿激素值高于健康犬的报告范围，考虑到血清渗透压，该值被认为不合适。排除利尿剂使用、肾脏疾病、肾上腺疾病和甲状腺功能减退等其他潜在原因后，认为特发性抗利尿激素分泌不当综合征是最可能的诊断。诊断后 2 年，该犬无临床症状，除了最低限度的饮食盐补充外，无需特殊治疗。该病例较为独特，因为其无全身或神经症状，治疗后预后良好，且使用了新型诊断测试。
