Hunter A G, Muggah H, Ivey B, Cox D M
CMAJ. 1986 Apr 1;134(7):753-6.
A study was carried out to develop proficiency in performing chorionic villus sampling (CVS) and to determine whether the risk for miscarriage was so high as to preclude a randomized clinical trial comparing CVS with amniocentesis. A total of 202 women who had decided to have induced abortions volunteered to either undergo CVS (101 women) or be a control (101). There were no differences between the two groups in factors that may affect the rate of miscarriage. CVS was performed an average of 9.8 days before abortion. The rate of fetal loss was significantly higher in the CVS group (p = 0.009). An analysis of the results as a function of the physician's experience over time showed that there were distinct learning phases. It may take longer than is generally recognized to acquire the expertise necessary to perform CVS with the lowest risk possible. Caution should be exercised before diagnostic CVS is offered to women who plan to continue their pregnancies.
开展了一项研究，旨在提高绒毛取样（CVS）操作的熟练度，并确定流产风险是否高到足以排除一项比较CVS与羊膜穿刺术的随机临床试验。共有202名决定进行人工流产的女性自愿选择接受CVS（101名女性）或作为对照（101名）。两组在可能影响流产率的因素方面没有差异。CVS平均在流产前9.8天进行。CVS组的胎儿丢失率显著更高（p = 0.009）。对结果随医生经验变化的分析表明存在明显的学习阶段。获得以尽可能低的风险进行CVS所需的专业技能可能比普遍认为的时间更长。在为计划继续妊娠的女性提供诊断性CVS之前应谨慎行事。
