Finland M
Am Rev Respir Dis. 1979 Sep;120(3):481-502. doi: 10.1164/arrd.1979.120.3.481.
An etiologic classification of acute pneumonia was presented and the relative importance of some of the causative agents was briefly reviewed. The early developments of the therapy of pneumococcal pneumonia with type-specific antisera, sulfonamide drugs, and antimicrobial drugs were reviewed, mostly from the experiences of the author at Boston City Hospital. Changes in the occurrence and relative importance of the pneumococcus as a cause of infections associated with bacteremia, empyema, and meningitis were demonstrated, based on cases observed at Boston City Hospital during 12 selected years between 1935 and 1972. These findings, among others, indicate that the pneumococcus is still one of the most important causes of serious bacterial infections and of mortality from such infections, particularly in the elderly. Some possible indications for polyvalent pneumococcal capsular polysaccharide vaccine were discussed, and the need for further extensive clinical and field trials to demonstrate its range of effectiveness was stressed.
本文提出了急性肺炎的病因分类，并简要回顾了一些致病因素的相对重要性。本文回顾了用型特异性抗血清、磺胺类药物和抗菌药物治疗肺炎球菌肺炎的早期进展，这些内容大多基于作者在波士顿市医院的经验。基于1935年至1972年期间在波士顿市医院观察的12个选定年份的病例，展示了肺炎球菌作为与菌血症、脓胸和脑膜炎相关感染病因的发生率和相对重要性的变化。这些发现以及其他一些发现表明，肺炎球菌仍然是严重细菌感染以及此类感染导致死亡的最重要原因之一，尤其是在老年人中。本文讨论了多价肺炎球菌荚膜多糖疫苗的一些可能适应证，并强调需要进行进一步广泛的临床和现场试验以证明其有效性范围。
