Blaser M J, Klaus B D, Jacobson J A, Kasworm E, LaForce F M
Antimicrob Agents Chemother. 1983 Aug;24(2):163-7. doi: 10.1128/AAC.24.2.163.
Thirty-four patients with community-acquired acute pneumonias were treated in a prospective, randomized trial with either cefadroxil, 500 mg twice daily, or cephalexin, 250 mg four times daily. In both groups of patients, the presence of chronic illnesses predisposing to pneumonia was common. Streptococcus pneumoniae was isolated from 65% of the initial sputum specimens, and most illnesses were of mild to moderate severity. All 19 cases treated with cefadroxil and all 15 cases treated with cephalexin were clinically cured, and adverse reactions to the medications were minimal. The success of these regimens suggests that outpatient use of oral cephalosporin therapy may be an appropriate treatment of patients with mild or moderate community-acquired pneumonia.
34例社区获得性急性肺炎患者参与了一项前瞻性随机试验，分别接受每日两次、每次500mg头孢羟氨苄或每日四次、每次250mg头孢氨苄的治疗。两组患者中，易引发肺炎的慢性疾病都很常见。65%的初始痰液标本中分离出肺炎链球菌，多数病情为轻至中度。接受头孢羟氨苄治疗的19例患者和接受头孢氨苄治疗的15例患者均临床治愈，药物不良反应极少。这些治疗方案的成功表明，门诊口服头孢菌素治疗可能是轻至中度社区获得性肺炎患者的一种合适治疗方法。
