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Protective effects of an mRNA vaccine candidate encoding H5HA clade 2.3.4.4b against the newly emerged dairy cattle H5N1 virus.

作者信息

Chiba Shiho, Kiso Maki, Yamada Shinya, Someya Kazuhiko, Onodera Yoshikuni, Yamaguchi Aya, Matsunaga Satoko, Jounai Nao, Yamayoshi Seiya, Takeshita Fumihiko, Kawaoka Yoshihiro

机构信息

Pandemic Preparedness, Infection and Advanced Research Center, the University of Tokyo (UTOPIA), Tokyo, 108-8639, Japan; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, 53711, USA; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.

Pandemic Preparedness, Infection and Advanced Research Center, the University of Tokyo (UTOPIA), Tokyo, 108-8639, Japan; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.

出版信息

EBioMedicine. 2024 Nov;109:105408. doi: 10.1016/j.ebiom.2024.105408. Epub 2024 Oct 30.

DOI:10.1016/j.ebiom.2024.105408

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11565041/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de8/11565041/a70d24dbab7a/gr1ae.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de8/11565041/a70d24dbab7a/gr1ae.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de8/11565041/a70d24dbab7a/gr1ae.jpg

相似文献

[1]

Protective effects of an mRNA vaccine candidate encoding H5HA clade 2.3.4.4b against the newly emerged dairy cattle H5N1 virus.

EBioMedicine. 2024-11

[2]

An mRNA vaccine candidate encoding H5HA clade 2.3.4.4b protects mice from clade 2.3.2.1a virus infection.

NPJ Vaccines. 2024-10-14

[3]

Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus.

Nat Med. 2024-10

[4]

Recombinant parainfluenza virus 5 expressing clade 2.3.4.4b H5 hemagglutinin protein confers broad protection against H5Ny influenza viruses.

J Virol. 2024-3-19

[5]

An Update on Highly Pathogenic Avian Influenza A(H5N1) Virus, Clade 2.3.4.4b.

J Infect Dis. 2024-9-23

[6]

Highly Pathogenic Avian Influenza Virus (H5N1) Clade 2.3.4.4b Introduced by Wild Birds, China, 2021.

Emerg Infect Dis. 2023-7

[7]

Avian influenza A (H5N1) virus in dairy cattle: origin, evolution, and cross-species transmission.

mBio. 2024-12-11

[8]

Detection and Monitoring of Highly Pathogenic Influenza A Virus 2.3.4.4b Outbreak in Dairy Cattle in the United States.

Viruses. 2024-8-29

[9]

Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus.

Nat Commun. 2024-5-23

[10]

Genomic characterization of highly pathogenic avian influenza A H5N1 virus newly emerged in dairy cattle.

Emerg Microbes Infect. 2024-12

引用本文的文献

[1]

Development of DNA and mRNA-LNP vaccines against an H5N1 clade 2.3.4.4b influenza virus.

J Virol. 2025-7-16

[2]

Dose-Dependent Effect of DNA Vaccine pVAX-H5 Encoding a Modified Hemagglutinin of Influenza A (H5N8) and Its Cross-Reactivity Against A (H5N1) Influenza Viruses of Clade 2.3.4.4b.

Viruses. 2025-2-27

本文引用的文献

[1]

Immunogenicity and biodistribution of lipid nanoparticle formulated self-amplifying mRNA vaccines against H5 avian influenza.

NPJ Vaccines. 2024-8-3

[2]

Pathogenicity and transmissibility of bovine H5N1 influenza virus.

Nature. 2024-9

[3]

Protective efficacy of a universal influenza mRNA vaccine against the challenge of H1 and H5 influenza A viruses in mice.

mLife. 2023-9-24

[4]

Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus.

Nat Commun. 2024-5-23

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