MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
J Environ Sci (China). 2025 May;151:252-272. doi: 10.1016/j.jes.2024.03.032. Epub 2024 Mar 26.
There is growing concern about the concept that exposure to environmental chemicals may be contributing to the obesity epidemic. However, there is no consensus on the obesogenic effects of emerging contaminants from a toxicological and environmental perspective. The potential human exposure and experimental evidence for obesogenic effects of emerging contaminants need to be systematically discussed. The main objective of this review is to provide recommendations for further subsequent policy development following a critical analysis of the literature for humans and experimental animals exposed to emerging contaminants. This article reviews human exposure to emerging contaminants (with a focus on antimicrobials, preservatives, water and oil repellents, flame retardants, antibiotics and bisphenols) and the impact of emerging contaminants on obesity. These emerging contaminants have been widely detected in human biological samples. Epidemiological studies provide evidence linking exposure to emerging contaminants to the risks of obesity in humans. Studies based on animal models and adipose cells show the obesogenic effects of emerging contaminants and identify modes of action by which contaminants may induce changes in body fat accumulation and lipid metabolic homeostasis. Some knowledge gaps in this area and future directions for further investigation are discussed.
人们越来越关注这样一种概念，即接触环境化学品可能是导致肥胖流行的一个因素。然而，从毒理学和环境角度来看，对于新兴污染物的致肥胖效应，尚未达成共识。需要系统地讨论新兴污染物的人体接触和具有致肥胖效应的实验证据。本综述的主要目的是在批判性地分析人类和实验动物接触新兴污染物的文献后，为进一步的后续政策制定提供建议。本文综述了人类接触新兴污染物（重点是抗菌剂、防腐剂、拒水拒油剂、阻燃剂、抗生素和双酚）以及新兴污染物对肥胖的影响。这些新兴污染物在人类生物样本中被广泛检测到。流行病学研究为接触新兴污染物与人类肥胖风险之间的关联提供了证据。基于动物模型和脂肪细胞的研究表明，新兴污染物具有致肥胖效应，并确定了污染物可能通过哪些方式诱导体内脂肪积累和脂质代谢稳态的变化。本文讨论了该领域的一些知识空白和未来进一步研究的方向。
