Goldberg David, Wilder Julius, Terrault Norah
Division of Digestive Health and Liver Diseases, University of Miami, Miami, FL, USA.
Division of Gastroenterology, Duke University, Durham, NC, USA.
Nat Rev Gastroenterol Hepatol. 2025 Feb;22(2):98-111. doi: 10.1038/s41575-024-01003-1. Epub 2024 Oct 31.
Morbidity and mortality from cirrhosis are substantial and increasing. Health disparities in cirrhosis and liver transplantation are reflective of inequities along the entire spectrum of chronic liver disease care, from screening and diagnosis to prevention and treatment of liver-related complications. The key populations experiencing disparities in health status and healthcare delivery include racial and ethnic minority groups, sexual and gender minorities, people of lower socioeconomic status and underserved rural communities. These disparities lead to delayed diagnosis of chronic liver disease and complications of cirrhosis (for example, hepatocellular carcinoma), to differences in treatment of chronic liver disease and its complications, and ultimately to unequal access to transplantation for those with end-stage liver disease. Calling out these disparities is only the first step towards implementing solutions that can improve health equity and clinical outcomes for everyone. Multi-level interventions along the care continuum for chronic liver disease are needed to mitigate these disparities and provide equitable access to care.
肝硬化导致的发病率和死亡率很高,且呈上升趋势。肝硬化和肝移植方面的健康差距反映了慢性肝病护理全流程中的不公平现象,涵盖从筛查、诊断到肝脏相关并发症的预防和治疗。在健康状况和医疗服务提供方面存在差距的关键人群包括种族和少数民族群体、性取向和性别少数群体、社会经济地位较低的人群以及服务不足的农村社区。这些差距导致慢性肝病诊断延迟和肝硬化并发症(例如肝细胞癌),导致慢性肝病及其并发症治疗上的差异,最终导致终末期肝病患者获得移植的机会不平等。指出这些差距只是朝着实施能够改善每个人的健康公平性和临床结果的解决方案迈出的第一步。需要在慢性肝病护理连续过程中采取多层次干预措施,以减轻这些差距并提供公平的医疗服务。