Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Lipids Health Dis. 2024 Oct 31;23(1):354. doi: 10.1186/s12944-024-02351-2.
This study was aimed at investigating the correlation between the occurrence of stroke and relative fat mass (RFM), a novel metric for determining total body fat.
This cross-sectional study employed the National Health and Nutrition Examination Survey (NHANES) dataset, which encompassed the years 2005 to 2018 to assess the independent relationship between RFM and stroke. Moreover, multinomial logistic regression, subgroup analysis, smooth curve fitting, and interaction testing were also used.
This study included 35,842 participants and 1,267 (3.53%) of them were diagnosed with stroke. Fully adjusted Models showed that RFM was positively associated with stroke (odds ratio [OR] = 1.02; 95% confidence interval [CI] = 1.01-1.03). The odds of having a stroke in quartile 4 were significantly elevated by 44%, compared to quartile 1 (OR = 1.44,95%CI:1.09-1.90). In addition, a subgroup analysis also demonstrated that age and BMI significantly impacted the association between RFM and stroke (P for interaction<0.01).
Elevated RFM is associated with increased odds of stroke, suggesting that RFM may have potential value in the prevention and management of stroke.
本研究旨在探讨卒中与相对脂肪量（RFM）之间的相关性，RFM 是一种新的衡量全身脂肪的指标。
本横断面研究采用了美国国家健康和营养调查（NHANES）数据集，该数据集涵盖了 2005 年至 2018 年的数据，用于评估 RFM 与卒中之间的独立关系。此外，还使用了多项逻辑回归、亚组分析、平滑曲线拟合和交互测试。
本研究纳入了 35842 名参与者，其中 1267 名（3.53%）被诊断为卒中。完全调整的模型显示，RFM 与卒中呈正相关（比值比 [OR] = 1.02；95%置信区间 [CI] = 1.01-1.03）。与 quartile 1 相比，quartile 4 的卒中发生风险显著升高 44%（OR = 1.44，95%CI：1.09-1.90）。此外，亚组分析还表明，年龄和 BMI 显著影响 RFM 与卒中之间的关联（交互检验 P<0.01）。
升高的 RFM 与卒中风险增加相关，表明 RFM 在卒中的预防和管理中可能具有潜在价值。
