Xu Hongjia, Ding Yiming, Zhang Ye, Li Jianwen, Zhou Shiyue, Wang Dewei, Xing Xinyue, Ma Xiaoyu, Wang Cunfu, Xu Shunliang
Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, China.
Front Neurol. 2025 May 16;16:1573027. doi: 10.3389/fneur.2025.1573027. eCollection 2025.
Serum klotho protein is a protein with anti-aging effects. Since the relationship between serum klotho and Stroke remains rather ambiguous, this research probed into the potential correlation between serum klotho concentration and Stroke.
This study employed a cross-sectional design and incorporated population data from the NHANES from 2007 to 2016. Weighted univariate and multivariate logistic regression models were utilized to inspect the relationship between klotho and Stroke. Stratified analyses and interaction tests were carried out to explore the latent correlation between klotho and Stroke. Finally, a fitted smooth curve was adopted to depict the non-linear relationship.
In this study, after excluding all the missing data, a total of 12,414 participants were encompassed, including 450 Stroke individuals. After adjusting for all covariates, higher klotho was associated with a lower prevalence of Stroke. According to the subgroup analyses and interaction tests, age, gender, race, BMI, hypertension, diabetes mellitus, family members, drinker and smoker were not significantly correlated with the influence of klotho and Stroke. After adjusting for all covariates, higher klotho was associated with a lower prevalence of stroke [OR: 0.68, 95% CI: 0.47-0.99].
This study disclosed the negative correlation between serum klotho protein levels and the prevalence of Stroke. Further prospective studies are requisite to investigate the impact of serum klotho protein levels on Stroke and determine the causal relationship.
血清α-klotho蛋白是一种具有抗衰老作用的蛋白质。由于血清α-klotho与中风之间的关系仍相当模糊，本研究探讨了血清α-klotho浓度与中风之间的潜在相关性。
本研究采用横断面设计，并纳入了2007年至2016年美国国家健康和营养检查调查（NHANES）的人群数据。使用加权单变量和多变量逻辑回归模型来检验α-klotho与中风之间的关系。进行分层分析和交互作用检验以探索α-klotho与中风之间的潜在相关性。最后，采用拟合平滑曲线来描述非线性关系。
在本研究中，排除所有缺失数据后，共纳入12414名参与者，其中包括450名中风患者。在对所有协变量进行调整后，较高的α-klotho水平与较低的中风患病率相关。根据亚组分析和交互作用检验，年龄、性别、种族、体重指数、高血压、糖尿病、家族史、饮酒者和吸烟者与α-klotho和中风之间的影响无显著相关性。在对所有协变量进行调整后，较高的α-klotho水平与较低的中风患病率相关[比值比（OR）：0.68，95%置信区间（CI）：0.47-0.99]。
本研究揭示了血清α-klotho蛋白水平与中风患病率之间的负相关关系。需要进一步的前瞻性研究来调查血清α-klotho蛋白水平对中风的影响并确定因果关系。
