Sriram Rashmi, Chandrashekar B S, C Madura, Gowda H Harshavardhan
Department of Dermatology, Venereology, Leprosy, Balagangadhara Swamiji Global Institute of Medical Sciences, Bengaluru, Karnataka, India.
Department of Dermatology, CUTIS Academy of Cutaneous Sciences, Bengaluru, Karnataka, India.
J Cutan Aesthet Surg. 2024 Jul-Sep;17(3):214-218. doi: 10.25259/jcas_122_23. Epub 2024 Aug 29.
Efficacy of fractional carbon dioxide laser and microfractional radiofrequency in treatment of acne scars is well substantiated. The objective of this study was to compare the efficacy and safety of carbon dioxide laser versus microfractional radiofrequency in treatment of acne scars in skin type 3,4.
Thirty-two patients of skin types 3-4 with grade 3 and 4 atrophic acne scars, of which 16 were treated with fractional carbon dioxide (CO) laser and 16 were treated with microfractional radiofrequency were retrospectively analyzed. All patients received either treatment 4 sessions at an interval of 4-6 weeks. Objective assessment was done with qualitative and quantitative Goodman and baron acne scar grading system by assessment of photographs at baseline and 3 months after last session.
All the data collected were entered in a Microsoft Excel worksheet and analyzed using R Software R-4.2.1. The study variables acne scar grades were described using frequency with percentage, acne scar scores were described using Mean with Standard deviation, and Median with interquartile range (IQR) (Q1-Q3). Since the data were ordinal, which is non-normal, hence, non-parametric tests are applied. To compare grades between the groups, Mann-Whitney U-test was applied.
There was no difference in the last session (after the treatment) between the groups, the Mann- Whitney U-test was 109.5 with -value of 0.484 >0.05. Therefore, there was no statistically significant difference between the microfractional radiofrequency and carbon dioxide laser group. There were 2 (12.5%) cases reported with post-inflammatory hyperpigmentation in the CO laser group and zero cases in the microfractional radiofrequency group.
分次二氧化碳激光和微分次射频治疗痤疮瘢痕的疗效已得到充分证实。本研究的目的是比较二氧化碳激光与微分次射频治疗3、4型皮肤痤疮瘢痕的疗效和安全性。
回顾性分析32例3-4型皮肤、伴有3级和4级萎缩性痤疮瘢痕的患者，其中16例接受分次二氧化碳（CO）激光治疗，16例接受微分次射频治疗。所有患者均接受4次治疗，间隔4-6周。通过在基线和最后一次治疗后3个月评估照片，采用定性和定量的古德曼和巴伦痤疮瘢痕分级系统进行客观评估。
所有收集的数据都录入到Microsoft Excel工作表中，并使用R软件R-4.2.1进行分析。研究变量痤疮瘢痕等级用频率和百分比描述，痤疮瘢痕评分用均值和标准差描述，中位数用四分位数间距（IQR）（Q1-Q3）描述。由于数据是有序的，即非正态的，因此应用非参数检验。为比较两组之间的等级，应用曼-惠特尼U检验。
两组在最后一次治疗后无差异，曼-惠特尼U检验值为109.5，P值为0.484>0.05。因此，微分次射频组和二氧化碳激光组之间无统计学显著差异。二氧化碳激光组报告有2例（12.5%）出现炎症后色素沉着，微分次射频组为0例。
