Sharma Saurabh, Kaur Jasleen, Kaur Tanreet, Bassi Roopam
Department of Dermatology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.
Department of Dermatology, Government Medical College, Amritsar, Punjab, India.
J Cutan Aesthet Surg. 2021 Jan-Mar;14(1):41-46. doi: 10.4103/JCAS.JCAS_147_19.
Though many treatment options are available for treating post-acne scars, optimized treatment still does not exist. Till date, comparative split-face studies, analyzing the efficacy of combined treatment modalities for acne scars with adequate sample size and with statistically significant results, are still lacking.
The aim of this study was to compare the effectiveness of the combined use of platelet-rich plasma (PRP) and fractional ablative CO laser (FACL) versus FACL in the management of acne scars and to study the safety of autologous PRP and FACL in the treatment of post-acne scars.
This was a randomized split-face trial study.
This study was conducted in 30 patients having Goodman and Baron's grade 3 and 4 acne scars. The efficacy of PRP in combination with FACL was compared to FACL alone in the treatment of post-acne scars. Right half of the patient's face was taken as the study side where FACL was performed followed by PRP injections. The left half of the same patient's face was taken as the control side where FACL was performed followed by normal saline injections.
Results were analyzed using Statistical Package for the Social Sciences (SPSS, Chicago).
At the time of enrollment, mean Goodman and Baron Acne Qualitative Grading Scale on study and control side was 3.80 with standard deviation (SD) of 0.40 at baseline. After completion of four treatment sessions, it was reduced to 2.43 (SD = 0.76) and 2.76 (SD = 0.49) on the study and control side, respectively. Improvement on both sides was statistically significant ( = 0.000).
There is no single proven modality for the effective treatment of post-acne scars. Combination of FACL with newer adjuvants such as PRP has definitive role in managing post-acne scars with better safety profile than FACL alone.
尽管有许多治疗方法可用于治疗痤疮后疤痕，但仍不存在优化的治疗方案。迄今为止，仍缺乏具有足够样本量且具有统计学显著结果的比较性半脸研究来分析联合治疗方式对痤疮疤痕的疗效。
本研究的目的是比较富血小板血浆（PRP）与剥脱性分数CO2激光（FACL）联合使用与FACL单独使用在痤疮疤痕管理中的有效性，并研究自体PRP和FACL治疗痤疮后疤痕的安全性。
这是一项随机半脸试验研究。
本研究对30例患有古德曼和巴伦3级和4级痤疮疤痕的患者进行。将PRP与FACL联合使用的疗效与单独使用FACL治疗痤疮后疤痕的疗效进行比较。患者面部的右半侧作为研究侧，先进行FACL治疗，然后注射PRP。同一患者面部的左半侧作为对照侧，先进行FACL治疗，然后注射生理盐水。
使用社会科学统计软件包（SPSS，芝加哥）对结果进行分析。
在入组时，研究侧和对照侧的古德曼和巴伦痤疮定性分级量表的平均基线值为3.80，标准差（SD）为0.40。在完成四个治疗疗程后，研究侧降至2.43（SD = 0.76），对照侧降至2.76（SD = 0.49）。两侧的改善均具有统计学显著性（P = 0.000）。
目前尚无单一被证实有效的治疗痤疮后疤痕的方法。FACL与PRP等新型辅助剂联合使用在治疗痤疮后疤痕方面具有明确作用，且安全性优于单独使用FACL。
