Brash-Arias David, García Luis I, Pérez-Estudillo César Antonio, Rojas-Durán Fausto, Aranda-Abreu Gonzalo Emiliano, Herrera-Covarrubias Deissy, Chi-Castañeda Donaji
Doctorado en Investigaciones Cerebrales, Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91190, Mexico;
Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91190, Mexico.
NeuroSci. 2024 Mar 8;5(1):71-86. doi: 10.3390/neurosci5010005. eCollection 2024 Mar.
The search for new therapies to reduce symptoms and find a cure for Parkinson's disease has focused attention on two key points: the accumulation of alpha-synuclein aggregates and astrocytes. The former is a hallmark of the disease, while the latter corresponds to a type of glial cell with an important role in both the prevention and development of this neurodegenerative disorder. Traditionally, research has focused on therapies targeting dopaminergic neurons. Currently, as more is known about the genetic and molecular factors and the neuroglial interaction in the disease, great emphasis has been placed on the neuroprotective role of astrocytes in the early stages of the disease and on the astrocytic capture of alpha-synuclein under both physiological and pathological conditions. This review aims to analyze the contribution of alpha-synuclein and astrocytes to the development and progression of Parkinson's disease, as well as to evaluate recent therapeutic proposals specifically focused on synucleopathies and astroglial cells as potential therapies for the disease.
寻找减轻帕金森病症状并找到治愈方法的新疗法，已将注意力集中在两个关键点上：α-突触核蛋白聚集体的积累和星形胶质细胞。前者是该疾病的一个标志，而后者是一种神经胶质细胞，在这种神经退行性疾病的预防和发展中都起着重要作用。传统上，研究集中在针对多巴胺能神经元的疗法上。目前，随着对该疾病的遗传和分子因素以及神经胶质相互作用的了解越来越多，人们高度重视星形胶质细胞在疾病早期阶段的神经保护作用，以及在生理和病理条件下星形胶质细胞对α-突触核蛋白的捕获。这篇综述旨在分析α-突触核蛋白和星形胶质细胞对帕金森病发展和进展的贡献，并评估最近专门针对突触核蛋白病和星形胶质细胞作为该疾病潜在疗法的治疗建议。
