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由嗜真菌阿皮奥毛孢子菌引起的脑膜炎：一例罕见病例报告

Meningitis Due to Apiotrichum mycotoxinivorans: A Rare Case Report.

作者信息

Kumar Ashok, Kumari Pankhuri, Gaba Manish

机构信息

Internal Medicine, Max Smart Super Specialty Hospital, New Delhi, IND.

Microbiology, Amrita Hospital Faridabad, Faridabad, IND.

出版信息

Cureus. 2024 Sep 30;16(9):e70573. doi: 10.7759/cureus.70573. eCollection 2024 Sep.

DOI:10.7759/cureus.70573
PMID:39483950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11525039/
Abstract

A young adult male presented as a case of meningitis in the background of a ventriculoperitoneal shunt in situ, uncontrolled type 1 diabetes and a history of treated abdominal tuberculosis. The patient presented with complaints of high-grade fever, non-projectile vomiting, headache and drowsiness. He was eventually diagnosed as a case of fungal meningitis. The patient's cerebrospinal fluid analysis (CSF) analysis revealed budding yeast cells and the culture revealed Apiotrichum mycotoxinivorans. This is a yeast-like fungus that is known to cause opportunistic infections in an immunocompromised host. This is a rare cause of fungal meningitis and very few cases have been reported worldwide. This is the first case of Apiotrichum mycotoxinivorans-associated meningitis reported from India.

摘要

一名年轻成年男性，因脑室腹腔分流管在位、1型糖尿病控制不佳且有腹部结核治疗史，而出现脑膜炎症状。患者主诉高热、非喷射性呕吐、头痛及嗜睡。他最终被诊断为真菌性脑膜炎。患者的脑脊液分析显示出芽酵母细胞，培养结果显示为食真菌毒素阿皮奥毛孢子菌。这是一种已知会在免疫功能低下宿主中引起机会性感染的类酵母真菌。这是真菌性脑膜炎的罕见病因，全球报道的病例很少。这是印度报道的首例食真菌毒素阿皮奥毛孢子菌相关性脑膜炎病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f885/11525039/bab01b647d6a/cureus-0016-00000070573-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f885/11525039/6f943cda5696/cureus-0016-00000070573-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f885/11525039/934b3bc0b250/cureus-0016-00000070573-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f885/11525039/4ef89b1041af/cureus-0016-00000070573-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f885/11525039/bab01b647d6a/cureus-0016-00000070573-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f885/11525039/6f943cda5696/cureus-0016-00000070573-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f885/11525039/934b3bc0b250/cureus-0016-00000070573-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f885/11525039/4ef89b1041af/cureus-0016-00000070573-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f885/11525039/bab01b647d6a/cureus-0016-00000070573-i04.jpg

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本文引用的文献

1
The first report of Apiotrichum mycotoxinivorans isolation from human cerebrospinal fluid.首例 Apiotrichum mycotoxinivorans 从人脑脊液中分离的报告。
Eur J Clin Microbiol Infect Dis. 2024 Mar;43(3):597-604. doi: 10.1007/s10096-023-04736-0. Epub 2023 Dec 16.
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Complete Genome Sequencing and Comparative Analysis of the Clinically-Derived Strain GMU1709.临床分离株 GMU1709 的全基因组测序及比较分析。
Front Cell Infect Microbiol. 2022 Feb 4;12:834015. doi: 10.3389/fcimb.2022.834015. eCollection 2022.
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A rare case of Trichosporon mycotoxinivorans and Cryptococcus neoformans co-infection in lung.
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