Department of Hepatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Department of Gastroenterology, Army Medical Center of PLA, Daping Hospital, Army Medical University, Chongqing, China.
Front Endocrinol (Lausanne). 2024 Oct 17;15:1395743. doi: 10.3389/fendo.2024.1395743. eCollection 2024.
Abnormalities in thyroid function affect bowel health. However, the relationships between thyroid hormone concentrations and the risk of developing chronic diarrhea and constipation remain unclear. Thus, the aim of this study was to investigate the relationships between thyroid hormone concentrations and the risk of developing chronic diarrhea and constipation in euthyroid US adults.
The data for this population-based study were taken from the National Health and Nutrition Examination Survey (NHANES) 2007-2010 datasets. The relationships between thyroid hormone concentrations and the risk of developing chronic diarrhea and constipation were examined via multivariate regression. Smoothed curve fitting and threshold effects analysis were used to test for nonlinear relationships and inflection points.
This study involved 4999 participants ranging in age from 20 to 80 years. Multivariate logistic regression analysis revealed a significant positive correlation between FT3 concentrations and the risk of developing chronic diarrhea [1.37 (1.00, 1.88), =0.049]. Multivariate linear regression analysis revealed a significant positive correlation between FT3 concentrations and the number of bowel movements [0.84 (0.39, 1.28), <0.001]. Using smoothed curve fitting and the two-stage regression model, we found a nonlinear relationship between FT4 concentrations and chronic diarrhea, with a breakpoint of 0.79 ng/dl.
There were associations between thyroid hormone concentrations and abnormal bowel habits, particularly between FT3 concentrations and the risk of developing chronic diarrhea. A higher FT3 level was associated with an increased risk of developing chronic diarrhea and more frequent bowel movements. To validate our results, further large-scale prospective studies are needed.
甲状腺功能异常会影响肠道健康。然而，甲状腺激素浓度与慢性腹泻和便秘发病风险之间的关系尚不清楚。因此，本研究旨在探讨美国甲状腺功能正常成年人的甲状腺激素浓度与慢性腹泻和便秘发病风险之间的关系。
本基于人群的研究数据来自 2007-2010 年全国健康和营养调查（NHANES）数据集。采用多元回归分析甲状腺激素浓度与慢性腹泻和便秘发病风险之间的关系。采用平滑曲线拟合和阈值效应分析来检验非线性关系和拐点。
本研究共纳入 4999 名年龄在 20 至 80 岁之间的参与者。多变量逻辑回归分析显示，FT3 浓度与慢性腹泻发病风险呈正相关[1.37（1.00，1.88），=0.049]。多变量线性回归分析显示，FT3 浓度与排便次数呈正相关[0.84（0.39，1.28），<0.001]。采用平滑曲线拟合和两阶段回归模型，发现 FT4 浓度与慢性腹泻之间存在非线性关系，转折点为 0.79ng/dl。
甲状腺激素浓度与异常肠道习惯之间存在关联，特别是 FT3 浓度与慢性腹泻发病风险之间存在关联。较高的 FT3 水平与慢性腹泻发病风险增加和排便次数增多有关。为验证我们的结果，需要进一步开展大规模前瞻性研究。
