Keetile Nicholas, Osuch Elzbieta, Lentoor Antonio G, Rasakanya Tsakani
Department of Pharmacology and Therapeutics, School of Medicine, Sefako Makgatho Health Sciences University, Ga-Rankuwa, Pretoria 0208, South Africa;
Department of Clinical Psychology, School of Medicine, Sefako Makgatho Health Sciences University, Ga-Rankuwa, Pretoria 0208, South Africa.
NeuroSci. 2023 Nov 7;4(4):296-304. doi: 10.3390/neurosci4040024. eCollection 2023 Dec.
The evidence links chemotherapy to cognitive impairment in breast cancer patients. This study assessed the link between subjective chemotherapy-related cognitive impairment and neuroinflammation in breast cancer patients.
In a correlational study, 113 patients aged 21 to 60 years on chemotherapy regimens completed the Functional Assessment of Cancer Therapy-Cognition Test (FACT-Cog) as a measure of subjective cognitive functioning at three time points (baseline- T, third cycle- T, and sixth cycle- T). The levels of inflammatory cytokines (interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumour necrosis factor-alpha (TNF-α)) were measured using an assay method and compared with the subjective cognitive impairment.
Midway through chemotherapy, higher levels of TNF-α were inversely linked with self-perceived cognitive performance, while higher levels of IL-1β were positively associated ( = 0.030). However, at the end of chemotherapy, only IL-8 ( = 0.50) was associated with higher self-perceived cognitive problems.
The specific roles that various cytokines and their interactions may play in neuroinflammation or neuroprotection require further investigation.
有证据表明化疗与乳腺癌患者的认知障碍有关。本研究评估了乳腺癌患者主观化疗相关认知障碍与神经炎症之间的联系。
在一项相关性研究中，113名年龄在21至60岁接受化疗方案的患者在三个时间点（基线 - T、第三个周期 - T和第六个周期 - T）完成了癌症治疗认知功能评估测试（FACT - Cog），作为主观认知功能的一项测量指标。使用一种检测方法测量炎症细胞因子（白细胞介素 - 1β（IL - 1β）、白细胞介素 - 6（IL - 6）、白细胞介素 - 8（IL - 8）和肿瘤坏死因子 - α（TNF - α））的水平，并与主观认知障碍进行比较。
化疗进行到一半时，较高水平的TNF - α与自我感知的认知表现呈负相关，而较高水平的IL - 1β呈正相关（P = 0.030）。然而，化疗结束时，只有IL - 8（P = 0.50）与较高的自我感知认知问题相关。
各种细胞因子及其相互作用在神经炎症或神经保护中可能发挥的具体作用需要进一步研究。
