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获得性穿通性胶原病的临床和组织病理学特征:一例报告

Clinical and Histopathologic Features of Acquired Perforating Collagenosis: A Case Report.

作者信息

Catolico Guillan Antonio Isidro C, Ang-Tiu Charlene

机构信息

Rizal Medical Center.

出版信息

Acta Med Philipp. 2023 Aug 29;57(8):81-84. doi: 10.47895/amp.vi0.4837. eCollection 2023.

DOI:10.47895/amp.vi0.4837
PMID:39484186
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11522600/
Abstract

A 51-year-old hypertensive and diabetic male patient, admitted due to acute kidney injury on top of chronic kidney disease, was referred to the dermatology service. He presented with a 3-month history of multiple discrete pruritic papules with keratotic plugs over the extensor aspects of the bilateral upper and lower extremities, initially managed as a case of scabies infestation but medications given provided no relief. Histopathologic analysis of a skin biopsy revealed findings of acquired perforating collagenosis. Resolution of lesions and pruritus were noted after starting on a topical corticosteroid ointment on the lesions, as well as hemodialysis to address the renal failure. Subsequent consults showed no recurrences and only a minor sequela of post-inflammatory hyperpigmentation.

摘要

一名51岁的男性患者,患有高血压和糖尿病,因慢性肾脏病基础上的急性肾损伤入院,后被转诊至皮肤科。他双上肢和双下肢伸侧出现多个散在的瘙痒性丘疹伴角质栓,病程3个月,最初被当作疥疮感染治疗,但所用药物未能缓解症状。皮肤活检的组织病理学分析显示为获得性穿通性胶原病。在皮损处开始外用糖皮质激素软膏以及进行血液透析以治疗肾衰竭后,皮损和瘙痒症状消退。后续复诊显示无复发,仅遗留轻微的炎症后色素沉着后遗症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e900/11522600/2ce8d4ed7578/AMP-57-8-4837-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e900/11522600/22eb20fe1e73/AMP-57-8-4837-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e900/11522600/2ce8d4ed7578/AMP-57-8-4837-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e900/11522600/22eb20fe1e73/AMP-57-8-4837-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e900/11522600/2ce8d4ed7578/AMP-57-8-4837-g002.jpg

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本文引用的文献

1
Dupilumab may be an alternative option in the treatment of acquired reactive perforating collagenosis combined with AD.度普利尤单抗可能是治疗伴有 AD 的获得性反应性穿孔性胶原病的一种替代选择。
Immun Inflamm Dis. 2022 Mar;10(3):e574. doi: 10.1002/iid3.574. Epub 2021 Dec 24.
2
Acquired reactive perforating collagenosis: A case report and review of the literature.获得性反应性穿通性胶原病:一例报告及文献复习
Medicine (Baltimore). 2020 May 29;99(22):e20391. doi: 10.1097/MD.0000000000020391.
3
Treatment of acquired reactive perforating dermatosis - a systematic review.
获得性反应性穿孔性皮肤病的治疗 - 系统评价。
J Dtsch Dermatol Ges. 2018 Jul;16(7):825-842. doi: 10.1111/ddg.13561. Epub 2018 Jun 21.
4
Cutaneous manifestations of chronic kidney disease.慢性肾脏病的皮肤表现
Clin Dermatol. 2008 May-Jun;26(3):255-64. doi: 10.1016/j.clindermatol.2007.10.017.
5
Acquired perforating dermatosis in a British dialysis population.英国透析人群中的获得性穿通性皮肤病
Br J Dermatol. 1996 Nov;135(5):671-7.