• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

研究物质使用对衰老的因果遗传效应。

Examining the causal genetic effects of substance use on aging.

作者信息

Balbona Jared V, Jeffries Paul, Gorelik Aaron J, Nelson Elliot C, Bogdan Ryan, Agrawal Arpana, Johnson Emma C

机构信息

Washington University School of Medicine in St. Louis, Dept. of Psychiatry.

Washington University in St. Louis, Department of Psychological & Brain Sciences.

出版信息

medRxiv. 2024 Oct 15:2024.10.14.24315472. doi: 10.1101/2024.10.14.24315472.

DOI:10.1101/2024.10.14.24315472
PMID:39484246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11527072/
Abstract

Substance use shortens lifespan, impedes health, and accelerates the biological aging process. We found widespread genetic correlations between alcohol, tobacco, cannabis, and opioid use and use disorders with indices of aging across the lifespan. There was evidence of tobacco and alcohol use and use disorders causally impacting physical, cognitive, and biological aging, with the effects of alcohol being more dependent on quantity of consumption; evidence of reverse causality was scant.

摘要

物质使用会缩短寿命、损害健康并加速生物衰老过程。我们发现，酒精、烟草、大麻和阿片类药物使用及使用障碍与整个生命周期的衰老指标之间存在广泛的遗传相关性。有证据表明，烟草和酒精使用及使用障碍对身体、认知和生物衰老有因果影响，酒精的影响更依赖于消费量；反向因果关系的证据很少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174b/11527072/cae1b89a2090/nihpp-2024.10.14.24315472v1-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174b/11527072/d5bfb856e3cb/nihpp-2024.10.14.24315472v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174b/11527072/3acd4bd6ef42/nihpp-2024.10.14.24315472v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174b/11527072/cae1b89a2090/nihpp-2024.10.14.24315472v1-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174b/11527072/d5bfb856e3cb/nihpp-2024.10.14.24315472v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174b/11527072/3acd4bd6ef42/nihpp-2024.10.14.24315472v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174b/11527072/cae1b89a2090/nihpp-2024.10.14.24315472v1-f0003.jpg

相似文献

1
Examining the causal genetic effects of substance use on aging.研究物质使用对衰老的因果遗传效应。
medRxiv. 2024 Oct 15:2024.10.14.24315472. doi: 10.1101/2024.10.14.24315472.
2
Using Mendelian randomization to explore the gateway hypothesis: possible causal effects of smoking initiation and alcohol consumption on substance use outcomes.利用孟德尔随机化探索门户假说：吸烟起始和饮酒对物质使用结果的可能因果效应。
Addiction. 2022 Mar;117(3):741-750. doi: 10.1111/add.15673. Epub 2021 Sep 29.
3
Post-traumatic stress and future substance use outcomes: leveraging antecedent factors to stratify risk.创伤后应激与未来物质使用结果：利用先行因素对风险进行分层
Front Psychiatry. 2024 Mar 8;15:1249382. doi: 10.3389/fpsyt.2024.1249382. eCollection 2024.
4
Using Mendelian randomization analysis to better understand the relationship between mental health and substance use: a systematic review.采用孟德尔随机化分析更好地理解心理健康与物质使用之间的关系：系统综述。
Psychol Med. 2021 Jul;51(10):1593-1624. doi: 10.1017/S003329172100180X. Epub 2021 May 25.
5
Investigating the genetic and causal relationship between initiation or use of alcohol, caffeine, cannabis and nicotine.研究饮酒、咖啡因、大麻和尼古丁的起始使用或使用与遗传和因果关系。
Drug Alcohol Depend. 2020 May 1;210:107966. doi: 10.1016/j.drugalcdep.2020.107966. Epub 2020 Mar 20.
6
Tobacco and cannabis use as moderators of the association between physical activity and alcohol use across the adult lifespan in the United States: NHANES, 2005-2016.美国成年人全生命周期内体力活动与饮酒量之间关联的调节因素：2005-2016 年 NHANES 调查。
Prev Med. 2022 Feb;155:106931. doi: 10.1016/j.ypmed.2021.106931. Epub 2021 Dec 24.
7
Modelling possible causality in the associations between unemployment, cannabis use, and alcohol misuse.模拟失业、大麻使用和酒精滥用之间关联中可能存在的因果关系。
Soc Sci Med. 2017 Feb;175:127-134. doi: 10.1016/j.socscimed.2017.01.001. Epub 2017 Jan 3.
8
Exploring a causal model in observational cohort data: The role of parents and peers in shaping substance use trajectories.探索观察性队列数据中的因果模型：父母和同伴在塑造物质使用轨迹中的作用。
Addict Behav. 2021 Jan;112:106597. doi: 10.1016/j.addbeh.2020.106597. Epub 2020 Aug 5.
9
Causal relationships between substance use and insomnia.物质使用与失眠之间的因果关系。
Drug Alcohol Depend. 2020 Sep 1;214:108151. doi: 10.1016/j.drugalcdep.2020.108151. Epub 2020 Jul 2.
10
Orbitofrontal cortex thickness and substance use disorders in emerging adulthood: causal inferences from a co-twin control/discordant twin study.成年早期眶额皮层厚度与物质使用障碍：来自同卵双生子对照/非同卵双生子研究的因果推断。
Addiction. 2021 Sep;116(9):2548-2558. doi: 10.1111/add.15447. Epub 2021 Mar 1.

本文引用的文献

1
The Genetically Informed Neurobiology of Addiction (GINA) model.成瘾的遗传神经生物学（GINA）模型。
Nat Rev Neurosci. 2023 Jan;24(1):40-57. doi: 10.1038/s41583-022-00656-8. Epub 2022 Nov 29.
2
Older Adult Substance Use Treatment First-Time Admissions Between 2008 and 2018.2008年至2018年间老年成人物质使用治疗首次入院情况
Am J Geriatr Psychiatry. 2022 Oct;30(10):1055-1063. doi: 10.1016/j.jagp.2022.03.003. Epub 2022 Mar 19.
3
Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics.
基于全基因组汇总统计数据，采用孟德尔随机化方法同时考虑相关和不相关的多效性效应。
Nat Genet. 2020 Jul;52(7):740-747. doi: 10.1038/s41588-020-0631-4. Epub 2020 May 25.
4
A Prospective Study of Health Conditions Related to Alcohol Consumption Cessation Among 97,852 Drinkers Aged 45 and Over in Australia.一项针对澳大利亚 97852 名 45 岁及以上饮酒者戒酒相关健康状况的前瞻性研究。
Alcohol Clin Exp Res. 2019 Apr;43(4):710-721. doi: 10.1111/acer.13981. Epub 2019 Mar 7.
5
The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.1990 - 2016年195个国家和地区因酒精和药物使用所致的全球疾病负担：全球疾病负担研究2016的系统分析
Lancet Psychiatry. 2018 Dec;5(12):987-1012. doi: 10.1016/S2215-0366(18)30337-7. Epub 2018 Nov 1.
6
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases.检测复杂性状和疾病之间的孟德尔随机化因果关系推断中广泛存在的水平 pleiotropy。
Nat Genet. 2018 May;50(5):693-698. doi: 10.1038/s41588-018-0099-7. Epub 2018 Apr 23.
7
Trends in substance use admissions among older adults.老年人物质使用入院情况的趋势。
BMC Health Serv Res. 2017 Aug 22;17(1):584. doi: 10.1186/s12913-017-2538-z.
8
Is biological aging accelerated in drug addiction?药物成瘾会加速生物衰老吗？
Curr Opin Behav Sci. 2017 Feb;13:34-39. doi: 10.1016/j.cobeha.2016.09.007.
9
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.LD评分回归在全基因组关联研究中区分混杂因素与多基因性。
Nat Genet. 2015 Mar;47(3):291-5. doi: 10.1038/ng.3211. Epub 2015 Feb 2.
10
Substance abuse among older adults.老年人中的药物滥用问题。
Clin Geriatr Med. 2014 Aug;30(3):629-54. doi: 10.1016/j.cger.2014.04.008. Epub 2014 Jun 12.