Wallace Wu Ashley, Mercedes Joann, Markowitz Morri
Children's Hospital at Montefiore, 111 E 210th Street, Bronx, NY 10467, United States.
Toxicol Rep. 2024 Oct 9;13:101761. doi: 10.1016/j.toxrep.2024.101761. eCollection 2024 Dec.
Lead is a known toxicant that affects all tissues in the body, most notably the brains of developing children. However, there are limited data on the dynamics of lead transfer via breastmilk and its short-term and long-term consequences. Much of the available data come from areas of the world where numerous sources of lead complicate our understanding of the effects of lead exposure via breast milk.
We present trends in blood lead levels in a breastfeeding dyad, where the only source of lead exposure identified was prior to pregnancy, without other known ongoing lead exposures for the lactating parent or infant.
In this case, all lead exposure in the infant was presumed to come from in utero transmission and breastfeeding; and infant blood lead levels varied significantly with initiation and interruption of breastfeeding. This case is discussed in the context of current models for predicting transfer of lead in breastmilk and highlights pathophysiologic considerations for understanding lead transfer in the breastfeeding dyad.
铅是一种已知的有毒物质,会影响身体的所有组织,对发育中的儿童大脑影响尤为显著。然而,关于铅通过母乳转移的动态过程及其短期和长期后果的数据有限。现有数据大多来自世界上铅源众多的地区,这使得我们难以理解通过母乳接触铅的影响。
我们展示了一对母乳喂养母婴的血铅水平变化趋势,其中确定的唯一铅暴露源是怀孕前,哺乳期母亲或婴儿没有其他已知的持续铅暴露情况。
在本病例中,婴儿的所有铅暴露被认为来自子宫内传播和母乳喂养;婴儿血铅水平随着母乳喂养的开始和中断而显著变化。结合当前预测母乳中铅转移的模型对该病例进行了讨论,并强调了理解母乳喂养母婴中铅转移的病理生理考虑因素。