Shangase Khanyiso Bright, Magwai Thabo, Oginga Fredrick Otieno, Xulu Khethelo Richman, Mpofana Thabisile
Department of Human Physiology, School of Laboratory Medicine and Medical Science, College of Health Science, University of KwaZulu-Natal, Durban 4041, South Africa;
National Health Laboratory Service, Department of Chemical Pathology, University of Kwa-Zulu Natal, Durban 4041, South Africa.
NeuroSci. 2022 Feb 9;3(1):111-118. doi: 10.3390/neurosci3010009. eCollection 2022 Mar.
Schizophrenia is a heterogeneous neuropsychiatric disorder, categorized by positive, negative, and cognitive symptoms. In trying to improve the diagnosis and treatment of schizophrenia, researchers have turned to "dual hit" models of schizophrenia that are able to reproduce all symptoms of the disorder. The main objective of this protocol is to present a transparent process on how we plan to review the existing international literature on the effectiveness of "dual hit" models used to induce schizophrenia on rodents.
Literature search strategies will be developed using medical search headings (MeSH). The MEDLINE (PubMed), EMBASE, and Google Scholar databases will be used to search for electronically published studies. We will search for studies involving inducing schizophrenic symptoms using "dual hit" rodent models (post-weaning social isolation and NMDA receptor antagonist). Studies will be screened by titles, abstracts, keywords, and synonyms followed by identifying the full-text articles. All studies that will pass quality assessment will be included. Data will be extracted by two authors independently and in duplicate from each eligible study to ensure that there is consistency between reviews. If the design and comparator are sufficiently homogenous for all studies, a meta-analysis will be conducted using a random-effect model.
The results of this review will contribute to the development of new "dual hit" models that will be able to characterize schizophrenia symptoms better. It will also shed light to researchers on new developments that need to be made in improving animal models of schizophrenia.
精神分裂症是一种异质性神经精神障碍，分为阳性、阴性和认知症状。为了改善精神分裂症的诊断和治疗，研究人员转向了能够重现该疾病所有症状的精神分裂症“双打击”模型。本方案的主要目的是展示一个透明的过程，说明我们计划如何回顾现有的关于用于在啮齿动物身上诱发精神分裂症的“双打击”模型有效性的国际文献。
将使用医学主题词（MeSH）制定文献检索策略。MEDLINE（PubMed）、EMBASE和谷歌学术数据库将用于搜索电子发表的研究。我们将搜索涉及使用“双打击”啮齿动物模型（断奶后社会隔离和NMDA受体拮抗剂）诱发精神分裂症症状的研究。将通过标题、摘要、关键词和同义词对研究进行筛选，随后确定全文文章。所有通过质量评估的研究都将被纳入。数据将由两位作者独立且重复地从每项符合条件的研究中提取，以确保综述之间的一致性。如果所有研究的设计和比较对象足够同质，将使用随机效应模型进行荟萃分析。
本综述的结果将有助于开发能够更好地表征精神分裂症症状的新“双打击”模型。它还将为研究人员揭示在改进精神分裂症动物模型方面需要取得的新进展。
