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免疫检查点的空间背景是独立于标准肿瘤-淋巴结-转移分期预测可切除结直肠癌患者总生存期的因素。

Spatial Context of Immune Checkpoints as Predictors of Overall Survival in Patients with Resectable Colorectal Cancer Independent of Standard Tumor-Node-Metastasis Stages.

机构信息

Department of Pancreatic Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

Laboratory of Digestive Surgery, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.

出版信息

Cancer Res Commun. 2024 Nov 1;4(11):3025-3035. doi: 10.1158/2767-9764.CRC-24-0270.

DOI:10.1158/2767-9764.CRC-24-0270
PMID:39485029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11589669/
Abstract

The identification of specific spatial patterns of immune checkpoint expression that correlate with overall survival in patients with colon cancer suggests a potential prognostic tool for risk stratification and treatment selection. These findings pave the way for the development of novel therapeutic strategies to enhance antitumor immune responses.

摘要

鉴定与结肠癌患者总生存期相关的特定免疫检查点表达的空间模式，提示了一种用于风险分层和治疗选择的潜在预后工具。这些发现为开发增强抗肿瘤免疫反应的新治疗策略铺平了道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f8/11589669/892a82a30a19/crc-24-0270_f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f8/11589669/df242af9ba13/crc-24-0270_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f8/11589669/d93ac4689329/crc-24-0270_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f8/11589669/1aa57c132f7e/crc-24-0270_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f8/11589669/892a82a30a19/crc-24-0270_f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f8/11589669/df242af9ba13/crc-24-0270_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f8/11589669/d93ac4689329/crc-24-0270_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f8/11589669/1aa57c132f7e/crc-24-0270_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f8/11589669/892a82a30a19/crc-24-0270_f4.jpg

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Clin Transl Med. 2023 Dec;13(12):e1515. doi: 10.1002/ctm2.1515.
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TCR-independent CD137 (4-1BB) signaling promotes CD8-exhausted T cell proliferation and terminal differentiation.TCR 非依赖性 CD137（4-1BB）信号促进 CD8 耗竭 T 细胞增殖和终末分化。
Immunity. 2023 Jul 11;56(7):1631-1648.e10. doi: 10.1016/j.immuni.2023.06.007. Epub 2023 Jun 30.
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Landscapes and mechanisms of CD8 T cell exhaustion in gastrointestinal cancer.
胃肠道癌症中 CD8 T 细胞耗竭的景观和机制。
Front Immunol. 2023 Apr 25;14:1149622. doi: 10.3389/fimmu.2023.1149622. eCollection 2023.
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Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer.PD-1 阻断在错配修复缺陷型结直肠癌中对免疫和基质细胞区室的重塑。
Cancer Cell. 2023 Jun 12;41(6):1152-1169.e7. doi: 10.1016/j.ccell.2023.04.011. Epub 2023 May 11.
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Immune profiling and prognostic model of pancreatic cancer using quantitative pathology and single-cell RNA sequencing.利用定量病理学和单细胞 RNA 测序对胰腺癌进行免疫分析和预后模型建立。
J Transl Med. 2023 Mar 21;21(1):210. doi: 10.1186/s12967-023-04051-4.
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