Cordovil Darciane Coelho, Bezerra Delana Andreza Melo, Bedran Rayssa Layna Silva, Junior Edvaldo Tavares Penha, Teixeira Dielle Monteiro, Lobo Patricia Santos, Siqueira Jones Anderson Monteiro, Ramos Adinaura Gama, Silva Amanda Mendes, Pinheiro Kenny Costa, Ferreira Jedson Cardoso, Junior Wanderley Dias Chagas, Barbagelata Luana Soares, Tavares Fernando Neto, Santos Mirleide Cordeiro, Soares Luana Silva
Seção de Ensino e Informação Científica, Programa de Pós-Graduação Em Virologia, Instituto Evandro Chagas, Ananindeua, Pará, Brasil.
Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde e Ambiente, Ministério da Saúde, Rodovia BR 316-KM 07, S/N, Levilândia, 67.030-000, Ananindeua, Pará, Brasil.
Braz J Microbiol. 2025 Mar;56(1):529-536. doi: 10.1007/s42770-024-01557-x. Epub 2024 Nov 1.
The coronavirus disease-2019 (COVID-19) pandemic has affected different sectors of society, and healthcare workers have been particularly impacted. This study aimed to describe the clinical, epidemiological, and molecular characteristics of SARS-CoV-2 infections among healthcare workers in Evandro Chagas Institute, a research reference center in Brazil, from October 2020 to July 2022. 845 samples were collected from individuals who presented clinical symptoms of respiratory infection. Nasopharyngeal positive samples were submitted through genome sequencing. Clinical, epidemiological, and the SARS-CoV-2 lineages (or variants) were analyzed. SARS-CoV-2 positivity was detected in 31.8% (269/845) of samples with a higher prevalence of females (60.2%). The highest SARS-CoV-2 positivity rates were reported in March 2021 (39%), January 2022 (65%), and July 2022 (56%). On clinical symptoms, arthralgia, chills, and diarrhea were statistically significantly detected in 2020; fever, runny nose, and arthralgia in 2021; runny nose, and cough in 2022. On molecular analysis of SARS-CoV-2, 66 samples (25.3%, 66/269) were sequenced and the most prevalent lineage was the Omicron, representing 57.6%. Studies on the epidemiological and clinical characteristics of HCW are essential to propose control measures and work management since research centers play a major role in surveillance to identify and monitor infectious diseases.
2019年冠状病毒病（COVID-19）大流行影响了社会的不同部门，医护人员受到的影响尤为显著。本研究旨在描述2020年10月至2022年7月期间，巴西研究参考中心埃万德罗·查加斯研究所医护人员中新型冠状病毒肺炎（SARS-CoV-2）感染的临床、流行病学和分子特征。从出现呼吸道感染临床症状的个体中采集了845份样本。对鼻咽阳性样本进行基因组测序。分析了临床、流行病学和SARS-CoV-2谱系（或变体）。在31.8%（269/845）的样本中检测到SARS-CoV-2阳性，女性患病率较高（60.2%）。报告的SARS-CoV-2阳性率最高的月份为2021年3月（39%）、2022年1月（65%）和2022年7月（56%）。在临床症状方面，2020年在统计学上显著检测到关节痛、寒战和腹泻；2021年检测到发热、流鼻涕和关节痛；2022年检测到流鼻涕和咳嗽。对SARS-CoV-2进行分子分析时，对66个样本（25.3%，66/269）进行了测序，最常见的谱系是奥密克戎，占57.6%。由于研究中心在识别和监测传染病的监测中发挥着重要作用，因此对医护人员的流行病学和临床特征进行研究对于提出控制措施和工作管理至关重要。
