Yao Jiali, Ji Linlin, Wang Guang, Ding Jin
Clinical Cancer Institute, Center for Translational Medicine, Naval Medical University, Shanghai, China.
Cancer Commun (Lond). 2025 Jan;45(1):15-42. doi: 10.1002/cac2.12613. Epub 2024 Nov 1.
Neutrophils are key mediators of the immune response and play essential roles in the development of tumors and immune evasion. Emerging studies indicate that neutrophils also play a critical role in the immunotherapy resistance in cancer. In this review, firstly, we summarize the novel classification and phenotypes of neutrophils and describe the regulatory relationships between neutrophils and tumor metabolism, flora microecology, neuroendocrine and tumor therapy from a new perspective. Secondly, we review the mechanisms by which neutrophils affect drug resistance in tumor immunotherapy from the aspects of the immune microenvironment, tumor antigens, and epigenetics. Finally, we propose several promising strategies for overcoming tumor immunotherapy resistance by targeting neutrophils and provide new research ideas in this area.
中性粒细胞是免疫反应的关键介质，在肿瘤发生和免疫逃逸中发挥着重要作用。新兴研究表明，中性粒细胞在癌症免疫治疗耐药性中也起着关键作用。在本综述中，首先，我们总结了中性粒细胞的新分类和表型，并从新的角度描述了中性粒细胞与肿瘤代谢、菌群微生态、神经内分泌和肿瘤治疗之间的调控关系。其次，我们从免疫微环境、肿瘤抗原和表观遗传学等方面综述了中性粒细胞影响肿瘤免疫治疗耐药性的机制。最后，我们提出了几种通过靶向中性粒细胞克服肿瘤免疫治疗耐药性的有前景的策略，并为该领域提供了新的研究思路。
