University Hospital Coventry & Warwickshire NHS Trust, Coventry, UK
Arden and GEM Commissioning Support Unit, Coventry, UK.
BMJ Open Gastroenterol. 2024 Oct 31;11(1):e001500. doi: 10.1136/bmjgast-2024-001500.
Colorectal cancer (CRC) poses a significant global health threat, necessitating early detection. Traditional diagnostic tools like optical colonoscopy have limitations prompting our '5G-SUCCEEDS' initiative to explore a novel approach involving remote colon capsule endoscopy (CCE).
This prospective feasibility study was conducted at a single hospital in England. Between December 2022 and September 2023, we introduced a remote CCE service within the 5G-SUCCEEDS framework. We undertook a feasibility study of CCE in patients with low-risk/moderate-risk CRC stratified by faecal haemoglobin. Outcomes included carbon footprint analysis (outlined through three potential clinical pathways) and patient-reported outcomes through structured questionnaires and interviews.
Among 25 participants, 88% expressed satisfaction with remote CCE. 82% were willing to have remote CCE if clinically indicated in future. CCE findings included adenomatous polyps (58%), normal results (17%) and diverticulosis (21%), with no cancers identified in this pilot. Notably, we found that the carbon footprint associated with delivery of CCE at home (pathway 3) was lower compared with CCE delivered in a clinical setting (pathway 2). A fully optimised, automated scaled-up pathway would combine the delivery and collection of CCE equipment within a local area to reduce the carbon footprint of the travel element by 75%. Moreover, the conversion rate into a colonoscopy pathway is not static and clinicians acknowledge that this could be as low as 28%. Carbon footprint is more favourable for home-delivered CCE in the optimised scenario, while less so when considering the need for additional procedures (colonoscopy conversion).
The 5G-SUCCEEDS initiative highlights the feasibility and advantages of home-based diagnostics using CCE.
结直肠癌(CRC)是一个全球性的健康威胁,需要早期检测。传统的诊断工具,如光学结肠镜检查,存在局限性,这促使我们的“5G-SUCCEEDS”计划探索一种新的方法,涉及远程结肠胶囊内镜(CCE)。
这是一项在英国一家医院进行的前瞻性可行性研究。在 2022 年 12 月至 2023 年 9 月期间,我们在 5G-SUCCEEDS 框架内引入了远程 CCE 服务。我们对低风险/中风险 CRC 患者进行了 CCE 的可行性研究,根据粪便血红蛋白进行分层。结果包括通过三种潜在的临床途径进行的碳足迹分析和通过结构化问卷和访谈进行的患者报告的结果。
在 25 名参与者中,88%对远程 CCE 表示满意。82%表示如果在未来临床上有需要,他们愿意接受远程 CCE。CCE 的发现包括腺瘤性息肉(58%)、正常结果(17%)和憩室病(21%),在这个试点中没有发现癌症。值得注意的是,我们发现在家中进行 CCE 交付(途径 3)的碳足迹低于在临床环境中进行 CCE 交付(途径 2)。完全优化、自动化扩展的途径将在一个局部区域内结合 CCE 设备的交付和收集,将旅行元素的碳足迹减少 75%。此外,转换为结肠镜检查途径的转化率不是静态的,临床医生承认这可能低至 28%。在优化的情况下,家庭交付的 CCE 碳足迹更有利,而在考虑需要额外程序(结肠镜检查转换)的情况下则不利。
5G-SUCCEEDS 计划突出了使用 CCE 进行家庭诊断的可行性和优势。