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围生期人类免疫缺陷病毒感染的神经认知结局。

Neurocognitive Outcomes Following Perinatal Human Immunodeficiency Virus Infection.

机构信息

Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, #0935, La Jolla, CA 92093, USA.

Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 15, New York, NY 10032, USA.

出版信息

Clin Perinatol. 2024 Dec;51(4):865-879. doi: 10.1016/j.clp.2024.08.004. Epub 2024 Sep 20.

Abstract

Perinatally acquired human immunodeficiency virus (HIV) has the potential to affect neurodevelopment and long-term cognitive and behavioral outcomes. Early, consistent viral suppression through antiretroviral therapy is a priority for protection of neurodevelopment. Monitoring of neurodevelopment and cognitive functioning, referral for appropriate interventions, caregiver/family support, and assessment of mental health, socioeconomic, and environmental risks are important to optimize health and well-being. Support for medication and health care adherence may be necessary to sustain best outcomes.

摘要

围产期获得的人类免疫缺陷病毒 (HIV) 有可能影响神经发育和长期的认知及行为结果。通过抗逆转录病毒疗法进行早期、持续的病毒抑制是保护神经发育的重点。监测神经发育和认知功能、提供适当干预的转介、照顾者/家庭支持,以及评估精神健康、社会经济和环境风险,对于优化健康和福祉非常重要。可能需要支持药物治疗和医疗保健依从性,以维持最佳结果。

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