围生期 HIV 治愈研究。
Research Toward a Cure for Perinatal HIV.
机构信息
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Ross 1133, 720 Rutland Avenue, Baltimore, MD 21205, USA.
Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, 1170, 720 Rutland Avenue, Baltimore, MD 21205, USA; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
出版信息
Clin Perinatol. 2024 Dec;51(4):895-910. doi: 10.1016/j.clp.2024.08.006. Epub 2024 Sep 13.
In virtually all people living with HIV-1 (PLWH), including children, HIV-1 integrates and becomes latent in CD4 T cells, forming a latent HIV-1 reservoir that current antiretroviral drugs and immune surveillance mechanisms cannot target. This latent infection in CD4 T cells renders HIV-1 infection lifelong and incurable. Consequently, there is intense research focused on identifying therapeutic strategies to reduce and control the latent reservoir, aiming to avert a lifetime of antiretroviral therapy for PLWH. This review discusses the global efforts for children and adolescents living with HIV-1.
在几乎所有感染 HIV-1 的人（PLWH）中，包括儿童，HIV-1 都会整合并潜伏在 CD4 T 细胞中，形成一个潜伏的 HIV-1 储存库，目前的抗逆转录病毒药物和免疫监测机制无法针对该储存库。CD4 T 细胞中的这种潜伏感染使 HIV-1 感染成为终身和不可治愈的。因此，人们正在积极研究识别治疗策略来减少和控制潜伏储存库，旨在避免 PLWH 终生接受抗逆转录病毒治疗。本文综述了针对感染 HIV-1 的儿童和青少年的全球努力。
Zotero 插件