2009 年至 2018 年 NHANES 中的尿酸与血压：一项横断面研究。
Uric acid and blood pressure in NHANES dated from 2009 to 2018: A cross-sectional research.
机构信息
Department of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, China.
Department of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, China.
出版信息
Nutr Metab Cardiovasc Dis. 2022 Nov;32(11):2568-2578. doi: 10.1016/j.numecd.2022.08.017. Epub 2022 Aug 31.
BACKGROUND AND AIM
This study aimed to explore the association between uric acid (UA) and blood pressure (BP), included systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP).
METHODS AND RESULTS
A cross-sectional study with 22,478 individuals aged from 12 to 80 years (11,443 males and 11,035 females) from the National Health and Nutrition Examination Survey (NHANES) was performed. Multiple linear regression analysis was applied to explore the relationship between UA and BP, Stratified analysis and interaction were performed based on gender, race, age, body mass index (BMI), and alcohol consumption. Significantly positively associations were presented in SBP(β, 0.84 [95% CI, 0.67, 1.00]), DBP(β, 0.23 [95% CI, 0.11, 0.36]), and MAP (β, 0.43 [95% CI, 0.31, 0.55]). The associations were much more stronger between UA and SBP in females (β, 1.04 [95% CI, 0.78, 1.30], p for interaction 0.0003), black group (β, 1.17 [95% CI, 0.77, 1.56], p for interaction 0.0296), age (≥45) group (β, 1.03 [95% CI, 0.68, 1.39], p for interaction <0.0001) and drinking group (β, 0.98 [95% CI, 0.75, 1.21], p for interaction <0.0001). The significant interactions were found between UA and DBP in gender and alcohol consumption (all p for interaction <0.05). In terms of MAP, the significant interactions were found in race, age, and alcohol consumption (all p for interaction <0.05).
CONCLUSIONS
A significantly positively association was found between UA and BP, including SBP, DBP, and MAP.
背景与目的
本研究旨在探讨尿酸（UA）与血压（BP）之间的关系，包括收缩压（SBP）、舒张压（DBP）和平均动脉压（MAP）。
方法和结果
本研究采用横断面研究设计，共纳入 22478 名年龄在 12 至 80 岁之间的个体（男性 11443 名，女性 11035 名），来自国家健康和营养检查调查（NHANES）。采用多元线性回归分析探讨 UA 与 BP 之间的关系，并进行了性别、种族、年龄、体重指数（BMI）和饮酒等因素的分层分析和交互作用分析。结果显示，SBP（β，0.84[95%CI，0.67，1.00]）、DBP（β，0.23[95%CI，0.11，0.36]）和 MAP（β，0.43[95%CI，0.31，0.55]）与 UA 呈显著正相关。在女性（β，1.04[95%CI，0.78，1.30]，p 交互作用=0.0003）、黑人组（β，1.17[95%CI，0.77，1.56]，p 交互作用=0.0296）、年龄（≥45 岁）组（β，1.03[95%CI，0.68，1.39]，p 交互作用<0.0001）和饮酒组（β，0.98[95%CI，0.75，1.21]，p 交互作用<0.0001）中，UA 与 SBP 之间的相关性更强。在性别和饮酒方面，UA 与 DBP 之间存在显著的交互作用（p 交互作用均<0.05）。在 MAP 方面，UA 与种族、年龄和饮酒之间存在显著的交互作用（p 交互作用均<0.05）。
结论
UA 与 BP 之间呈显著正相关，包括 SBP、DBP 和 MAP。
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